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• W2079087277 abstract "A paclitaxel-loaded poly (epsilon]-caprolactone)(PCL)/pluronic F68 (F68) nanoparticle formulation was prepared as an intratumoral delivery system to assess its potential for future neoadjuvant chemotherapy application in the treatment of breast cancer. Paclitaxel-loaded nanoparticles were prepared by a solvent evaporation method using the self-synthesized PCL/F68 compound. Prepared nanoparticles were spherical with a rough, porous surface. As described in our earlier study, F68 was incorporated into the PCL matrix as both a pore-forming agent and to enhance drug release from the particles. A murine breast cancer model has shown that when using equivalent paclitaxel doses, paclitaxel-loaded PCL/F68 nanoparticles administered by a single intratumoral injection were more efficient in impeding tumor development than conventional paclitaxel injections administered by multiple intraperitoneal injections. In conclusion, paclitaxel-loaded PCL/F68 nanoparticles can be delivered intratumorally and they effectively prevent tumor cell growth and establishment in a localized area. This treatment shows promise as a future neoadjuvant chemotherapy application in the treatment of breast cancer." @default.
• W2079087277 created "2016-06-24" @default.
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• W2079087277 date "2010-03-01" @default.
• W2079087277 modified "2023-10-16" @default.
• W2079087277 title "Effective antitumor activity of paclitaxel-loaded poly (ε-caprolactone)/pluronic F68 nanoparticles after intratumoral delivery into the murine breast cancer model" @default.
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• W2079087277 doi "https://doi.org/10.1097/cad.0b013e32833410a2" @default.
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