Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079087567> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2079087567 abstract "It is well established that mechanical forces can regulate cell growth and guide tissue remodeling, yet little is known about how mechanical signals act at the cell surface membrane to produce biochemical changes in the cell. To explore this question, I used a mouse embryonic F9 vinculin-deficient cell line (gamma229), which, unlike wild-type cells, shows no fibronectin-dependent cell spreading. The wild-type cell line exhibited a twofold increase in area over four hours. I observed (i) an earlier rise in intracellular free calcium from approximately 0.2 to approximately 3 microm in wild-type compared with gamma229 cells, thus similar calcium levels after 4 h; (ii) an initial higher ratio of p-MAP/MAP-Kinase for gamma229, but similar FA-Kinase activation; and (iii) a marginal change in intracellular pH [pH](i) in both F9 cell lines. When I applied controlled local stresses directly to integrin receptors using RGD-coated magnetic beads, they displaced to a lesser extent in wild-type than in gamma229 cells. Both F9 cell lines showed a small stress-dependent rise in [Ca2+]i levels and similar PKA-c activity. In summary, the mechanical linkage of integrin-vinculin-cytoskeleton seemed not to be essential for chemical signal transduction." @default.
- W2079087567 created "2016-06-24" @default.
- W2079087567 creator A5015345229 @default.
- W2079087567 date "2002-03-01" @default.
- W2079087567 modified "2023-09-27" @default.
- W2079087567 title "THE COUPLING OF VINCULIN TO THE CYTOSKELETON IS NOT ESSENTIAL FOR MECHANO-CHEMICAL SIGNALING IN F9 CELLS" @default.
- W2079087567 cites W1485823898 @default.
- W2079087567 cites W1487858339 @default.
- W2079087567 cites W1526496445 @default.
- W2079087567 cites W1532214345 @default.
- W2079087567 cites W1537459781 @default.
- W2079087567 cites W1541979189 @default.
- W2079087567 cites W1963756782 @default.
- W2079087567 cites W1982406314 @default.
- W2079087567 cites W1983854516 @default.
- W2079087567 cites W2000304973 @default.
- W2079087567 cites W2017734122 @default.
- W2079087567 cites W2026327508 @default.
- W2079087567 cites W2031741707 @default.
- W2079087567 cites W2050471908 @default.
- W2079087567 cites W2052766715 @default.
- W2079087567 cites W2053742656 @default.
- W2079087567 cites W2066367871 @default.
- W2079087567 cites W2067447488 @default.
- W2079087567 cites W2077442105 @default.
- W2079087567 cites W2087630349 @default.
- W2079087567 cites W2109803081 @default.
- W2079087567 cites W2112093320 @default.
- W2079087567 cites W2142714350 @default.
- W2079087567 cites W2168918180 @default.
- W2079087567 cites W2185271266 @default.
- W2079087567 doi "https://doi.org/10.1006/cbir.2001.0854" @default.
- W2079087567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11991656" @default.
- W2079087567 hasPublicationYear "2002" @default.
- W2079087567 type Work @default.
- W2079087567 sameAs 2079087567 @default.
- W2079087567 citedByCount "11" @default.
- W2079087567 countsByYear W20790875672012 @default.
- W2079087567 countsByYear W20790875672014 @default.
- W2079087567 countsByYear W20790875672018 @default.
- W2079087567 countsByYear W20790875672020 @default.
- W2079087567 crossrefType "journal-article" @default.
- W2079087567 hasAuthorship W2079087567A5015345229 @default.
- W2079087567 hasConcept C142669718 @default.
- W2079087567 hasConcept C1491633281 @default.
- W2079087567 hasConcept C151166631 @default.
- W2079087567 hasConcept C181080969 @default.
- W2079087567 hasConcept C185592680 @default.
- W2079087567 hasConcept C189165786 @default.
- W2079087567 hasConcept C195687474 @default.
- W2079087567 hasConcept C2777979848 @default.
- W2079087567 hasConcept C54355233 @default.
- W2079087567 hasConcept C55493867 @default.
- W2079087567 hasConcept C62478195 @default.
- W2079087567 hasConcept C6997183 @default.
- W2079087567 hasConcept C79879829 @default.
- W2079087567 hasConcept C8035138 @default.
- W2079087567 hasConcept C81885089 @default.
- W2079087567 hasConcept C86492073 @default.
- W2079087567 hasConcept C86803240 @default.
- W2079087567 hasConcept C95444343 @default.
- W2079087567 hasConceptScore W2079087567C142669718 @default.
- W2079087567 hasConceptScore W2079087567C1491633281 @default.
- W2079087567 hasConceptScore W2079087567C151166631 @default.
- W2079087567 hasConceptScore W2079087567C181080969 @default.
- W2079087567 hasConceptScore W2079087567C185592680 @default.
- W2079087567 hasConceptScore W2079087567C189165786 @default.
- W2079087567 hasConceptScore W2079087567C195687474 @default.
- W2079087567 hasConceptScore W2079087567C2777979848 @default.
- W2079087567 hasConceptScore W2079087567C54355233 @default.
- W2079087567 hasConceptScore W2079087567C55493867 @default.
- W2079087567 hasConceptScore W2079087567C62478195 @default.
- W2079087567 hasConceptScore W2079087567C6997183 @default.
- W2079087567 hasConceptScore W2079087567C79879829 @default.
- W2079087567 hasConceptScore W2079087567C8035138 @default.
- W2079087567 hasConceptScore W2079087567C81885089 @default.
- W2079087567 hasConceptScore W2079087567C86492073 @default.
- W2079087567 hasConceptScore W2079087567C86803240 @default.
- W2079087567 hasConceptScore W2079087567C95444343 @default.
- W2079087567 hasLocation W20790875671 @default.
- W2079087567 hasLocation W20790875672 @default.
- W2079087567 hasOpenAccess W2079087567 @default.
- W2079087567 hasPrimaryLocation W20790875671 @default.
- W2079087567 hasRelatedWork W196236975 @default.
- W2079087567 hasRelatedWork W1967922151 @default.
- W2079087567 hasRelatedWork W2005496211 @default.
- W2079087567 hasRelatedWork W2030916139 @default.
- W2079087567 hasRelatedWork W2079087567 @default.
- W2079087567 hasRelatedWork W2155494616 @default.
- W2079087567 hasRelatedWork W2164726673 @default.
- W2079087567 hasRelatedWork W2180771258 @default.
- W2079087567 hasRelatedWork W2406691634 @default.
- W2079087567 hasRelatedWork W4282919138 @default.
- W2079087567 isParatext "false" @default.
- W2079087567 isRetracted "false" @default.
- W2079087567 magId "2079087567" @default.
- W2079087567 workType "article" @default.