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• W2079089192 abstract "The mast cell function-associated antigen (MAFA) is a glycoprotein first identified on the membrane of rat mucosal-type mast cells (RBL-2H3 line). MAFA clustering causes a dose-dependent inhibition of these cells' secretory response to the type I Fcϵ receptor (FcϵRI) stimulus. The inhibition has earlier been shown to take place upstream to the production step of inositol phosphates in the FcϵRI coupling cascade. To resolve further the mechanism of action of MAFA, we have investigated the events prior to the activation of phospholipase C. Activities of the non-receptor protein tyrosine kinases Lyn and Syk in untreated cells were compared with those where the FcϵRI, MAFA or both were clustered. Syk tyrosine phosphorylation and activation, as well as LAT (linker for activation of T cells) tyrosine phosphorylation, both induced by FcϵRI clustering, were found to be reduced upon MAFA clustering. In contrast, the activity of the Src homology domain 2 (SH2)-containing protein tyrosine phosphatase (SHP-2) increased. MAFA clustering also enhanced the co-isolation of SHP-2 and Syk with tyrosine-phosphorylated MAFA in both untreated and FcϵRI-stimulated cells. SHP-2 caused a decline in the FcϵRI-induced tyrosine phosphorylation of Syk, at least under in vitro conditions. Taken together, these results suggest that one possible mechanism by which MAFA affects the FcϵRI stimulation cascade is suppression of Syk activity, i.e. MAFA clustering leads SHP-2 to act on Syk, thereby reducing its tyrosine phosphorylation and its activity." @default.
• W2079089192 created "2016-06-24" @default.
• W2079089192 creator A5021244474 @default.
• W2079089192 creator A5042658750 @default.
• W2079089192 date "2001-05-01" @default.
• W2079089192 modified "2023-10-11" @default.
• W2079089192 title "The protein tyrosine kinase Syk activity is reduced by clustering the mast cell function-associated antigen" @default.
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• W2079089192 doi "https://doi.org/10.1002/1521-4141(200105)31:5<1571::aid-immu1571>3.0.co;2-u" @default.
• W2079089192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11465115" @default.
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