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- W2079089904 abstract "A relationship was found between the formation of lipid peroxides and the activities of drug-metabolizing enzymes in liver microsomes of rats. Induction of lipid peroxidation by incubation with ferrous ion led to a sharp decline in the ability of the microsomal enzyme system to demethylate ethylmorphine. Inhibition of lipid peroxidation by EDTA increased the enzyme activity about two-fold. Addition of EDTA (0.1 mM) to the incubation mixture produced marked changes in the Michaelis constants of drug-metabolizing enzymes and in inhibition constants of SKF 525-A for drug-metabolizing enzymes." @default.
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- W2079089904 date "1973-12-01" @default.
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- W2079089904 title "Effects of lipid peroxidation on activities of drug-metabolizing enzymes in liver microsomes of rats" @default.
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- W2079089904 doi "https://doi.org/10.1016/0006-2952(73)90094-4" @default.
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