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• W2079094767 abstract "Background and purpose Radiotherapy of thoracic and chest-wall tumours increases the long-term risk of radiation-induced heart disease. The aim of this study was to investigate the long-term effect of local heart irradiation on cardiac mitochondria. Methods C57BL/6 and atherosclerosis-prone ApoE−/− mice received local heart irradiation with a single X-ray dose of 2 Gy. To investigate the low-dose effect, C57BL/6 mice also received a single heart dose of 0.2 Gy. Functional and proteomic alterations of cardiac mitochondria were evaluated after 40 weeks, compared to age-matched controls. Results The respiratory capacity of irradiated C57BL/6 cardiac mitochondria was significantly reduced at 40 weeks. In parallel, protein carbonylation was increased, suggesting enhanced oxidative stress. Considerable alterations were found in the levels of proteins of mitochondria-associated cytoskeleton, respiratory chain, ion transport and lipid metabolism. Radiation induced similar but less pronounced effects in the mitochondrial proteome of ApoE−/− mice. In ApoE−/−, no significant change was observed in mitochondrial respiration or protein carbonylation. The dose of 0.2 Gy had no significant effects on cardiac mitochondria. Conclusion This study suggests that ionising radiation causes non-transient alterations in cardiac mitochondria, resulting in oxidative stress that may ultimately lead to malfunctioning of the heart muscle." @default.
• W2079094767 created "2016-06-24" @default.
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• W2079094767 date "2013-03-01" @default.
• W2079094767 modified "2023-10-02" @default.
• W2079094767 title "Ionising radiation induces persistent alterations in the cardiac mitochondrial function of C57BL/6 mice 40weeks after local heart exposure" @default.
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• W2079094767 doi "https://doi.org/10.1016/j.radonc.2013.01.017" @default.
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