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- W2079095172 abstract "Cytokine interferon gamma (IFN-γ) is pivotal in the defence against viruses and intracellular pathogens and an age-related decreased IFN-γ production may explain the increased infectious disease morbidity and mortality in the elderly. Therefore, we performed a series of clinical experiments evaluating the influence of age and health status on IFN-γ production following in vitro stimulation with influenza vaccine or endotoxin. Both healthy and frail elderly people produced significantly lower amounts of IFN-γ following ex vivo stimulation with influenza vaccine or endotoxin. We conclude that ageing is accompanied by a decreased capacity to produce IFN-γ. This may explain the increased incidence and case-fatality caused by viruses and intracellular pathogens in the elderly." @default.
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- W2079095172 date "2001-01-01" @default.
- W2079095172 modified "2023-09-27" @default.
- W2079095172 title "Reduced IFN-γ production in elderly people following in vitro stimulation with influenza vaccine and endotoxin" @default.
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- W2079095172 doi "https://doi.org/10.1016/s0047-6374(00)00204-9" @default.
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