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- W2079095991 abstract "When bovine endothelial cells isolated from carotid arteries were cultured with a low density lipoprotein(LDL)-deficient serum for 2 days, their intracellular free cholesterol levels decreased. Under this condition, exposure of the endothelial cells to simvastatin and pravastatin, HMG-CoA reductase inhibitors used clinically, resulted in further decrease in the free cholesterol levels. The migration activity was enhanced in the cells cultured with the LDL-deficient serum and it was more enhanced in the cells treated with HMG-CoA reductase inhibitors under the LDL-deficient serum condition. These results suggest that cholesterol plays a negative role in wound healing in arterial walls and acts as one of the risk factors for arteriosclerosis." @default.
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- W2079095991 date "1994-09-01" @default.
- W2079095991 modified "2023-09-25" @default.
- W2079095991 title "Enhancement of Migration Activity in Cholesterol-Poor Endothelial Cells by Pretreating with HMG-CoA Reductase Inhibitors" @default.
- W2079095991 doi "https://doi.org/10.1006/bbrc.1994.2331" @default.
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