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• W2079097733 abstract "A straightforward cleavage method for N- acylated peptides based on the phenylthiohydantoin (PTH) formation is presented. The procedure could be applied to acid-stable resins, such as TentaGel HL-NH[Formula: see text]. We designed a cleavable linker that consists of a lysine residue with the [Formula: see text]-amino group blocked by Boc, whereas the [Formula: see text]-amino group is used for peptide synthesis. After the peptide assembly is completed, the protecting groups in peptide side chains are removed using trifluoroacetic acid, thus liberating also the [Formula: see text]-amino group of the lysine in the linker. Then the reaction with phenyl isothiocyanate followed by acidolysis causes an efficient peptide release from the resin as a stable PTH derivative. Furthermore, the application of a fixed charge tag in the form of 2-(4-aza-1-azoniabicyclo[2.2.2]octylammonium)acetyl group increases ionization efficiency and reduces the detection limit, allowing ESI-MS/MS sequencing of peptides in the subfemtomolar range. The proposed strategy is compatible with standard conditions during one-bead-one-compound peptide library synthesis. The applicability of the developed strategy in combinatorial chemistry was confirmed using a small training library of [Formula: see text]-chymotrypsin substrates." @default.
• W2079097733 created "2016-06-24" @default.
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• W2079097733 date "2013-05-21" @default.
• W2079097733 modified "2023-10-07" @default.
• W2079097733 title "New method of peptide cleavage based on Edman degradation" @default.
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• W2079097733 doi "https://doi.org/10.1007/s11030-013-9453-y" @default.
• W2079097733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3713267" @default.
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