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- W2079102707 abstract "Abstract Pathological glomerular alterations have been found in mice infected with Plasmodium berghei berghei (NK65), after rapid clearance of the parasites by 4 days sulfa drug administration. Generalized diffuse or disseminated IgM deposits in the glomeruli were observed in the cured mice. The deposits were irregular, nodular, granular, and beaded; the typical linear patterns were not observed. Malarial antigen was also detected in the glomeruli of 7 out of 15 of these mice. IgG was not found in the glomeruli in any of the mice throughout the course of the experiment. Histological studies demonstrated generalized hypercellularity in the glomeruli with massive increase of the mesangial matrix. Polymorphonuclear leukokytes were observed in the capillary spaces. Electron microscopically, hypertrophy and microvillous networks of the endothelial cell were seen. Abnormal cytoplasmic extensions from mesangial cells into the capillary lumen or into endothelial cells were observed. Patchy expansions of the basement membrane associated with fusion of the foot processes of epithelial cells were found. Epithelial cells showed prominent vacuolation." @default.
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- W2079102707 date "1974-04-01" @default.
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- W2079102707 title "Plasmodium berghei: Experimental rodent model for malarial renal immunopathology" @default.
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- W2079102707 doi "https://doi.org/10.1016/0014-4894(74)90022-8" @default.
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