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- W2079103416 abstract "The Dispatch™ Catheter is a new local drug delivery device which allows for the prolonged infusion of therapeutic agents at an angioplasty site while still maintaining distal coronary perfusion. To determine the efficacy of this device in dissolving intraluminal clot with local urokinase infusion, 29 patients with thrombus-containing stenoses were treated with the Dispatch™ catheter either prior to (n = 16) or following (n = 13) coronary angioplasty or directional atherectomy. The study group consisted of 15 males and 14 females with a mean age of 58.1 years. Clinical diagnoses included unstable angina (n = 14), acute myocardial infarction (n = 11) or post infarction angina (n = 4). Urokinase was infused at either 10,000 unitlcc (n = 22) or 30,000 units/cc (n = 7) at 0.5 cc/min for up to 30 minutes. All coronary angiograms were analyzed to determine Thrombus Score (0 – 3), TIMI flow, and quantitative coronary measurements pre and post Dispatch™ therapy. (Thrombus Score: 0 = no thrombus, 1 = possible thrombus, 2 = definite thrombus < 3 mm, 3 = definite thrombus > 3 mm). Infusions of urokinase for 30 mins were well tolerated in 25 patients without adverse clinical, hemodynamic or electrical sequelae. In the remaining 4 patients, limited infusions were tolerated only for 2.5, 5, 6 and 11 mins because of chest pain with EKG changes secondary either to sidebranch occlusion or inadequete distal perfusion. For the entire study group, Thrombus Score decreased from 2.0 ± 0.7 to 0.5 ± 0.8, TIMI Flow increased from 2.1 ± 1.3 to 3.0 ± 0.0, and minimal lumen diameter increased from 0.70 ± 0.59 to 1.58 ± 0.51 mm (all p < 0.01). Distal embolization, no-reflow, and abrupt closure were not observed in any patient. Reduction of thrombus-containing stenoses and dissolution of intracoronary thrombus can be rapidly achieved in patients with infusions of limited quantities of urokinase with the Dispatch™ catheter. Sidebranch occlusion and inability to dilate coronary stenoses with inadequate distal perfusion may limit the duration of drug infusion with this device." @default.
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- W2079103416 date "1995-02-01" @default.
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- W2079103416 title "1001-26 Local Dissolution of Intracoronary Thrombus with Urokinase Using the Dispatch™ Catheter: Clinical Studies" @default.
- W2079103416 doi "https://doi.org/10.1016/0735-1097(95)92900-p" @default.
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