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• W2079103662 abstract "Mutations in the DJ-1 gene have been implicated in the PARK7-linked autosomal recessive form of Parkinson's disease (PD). The molecular properties of DJ-1WT, DJ-1L166P, and a newly identified disease-causing mutant DJ-1M26I were explored after they were transiently expressed in mammalian cells. Treatment of intact, living cells with the chemical crosslinker disuccinimidyl suberate (DSS) revealed that DJ-1WT and mutant DJ-1M26I were present as stable homodimers; DJ-1L166P in particular tended to form high-order complexes as well. In contrast to DJ-1L166P that is quickly degraded by the proteasome, DJ-1M26I was found to be an efficiently expressed and stable variant of DJ-1, suggesting that these mutations have distinct biochemical effects on DJ-1. We further provide evidence that in human brain, under nondenaturing conditions, DJ-1 is present in high molecular weight (HMW) complexes of approximately 250–700 kDa containing parkin, another PD-associated protein." @default.
• W2079103662 created "2016-06-24" @default.
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• W2079103662 date "2004-11-01" @default.
• W2079103662 modified "2023-10-16" @default.
• W2079103662 title "Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain" @default.
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• W2079103662 doi "https://doi.org/10.1016/j.mcn.2004.06.014" @default.
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