FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079103750> ?p ?o ?g. }

• W2079103750 endingPage "102" @default.
• W2079103750 startingPage "87" @default.
• W2079103750 abstract "Amyotrophic lateral sclerosis with dementia (ALS‐D) is a non‐Alzheimer‐type dementia characterized by both frontotemporal degeneration and motor neuron disease and marked by ubiquitin‐positive, tau‐ and α‐synuclein‐negative intraneuronal inclusions and dystrophic neurites. New neuropathological diagnostic criteria for ALS‐D are proposed on the basis of the present investigation of 28 autopsy cases. Clinical features included those of typical ALS‐D, primary lateral sclerosis, atypical ALS with frontotemporal atrophy and atypical Pick's disease without Pick's bodies. Macroscopically anterior frontotemporal atrophy was observed involving or not involving the precentral gyrus. Microscopically non‐specific neuronal loss and gliosis with spongiosis were seen, particularly in superficial layers II and III of the frontotemporal cortices. Diffuse fibrous gliosis was seen in the frontotemporal white matter. The substantia nigra and amygdala showed neuronal loss and gliosis. In all 28 cases, degeneration of both the lower and upper motor neuron systems, consistent with classic sporadic ALS, was present. The distribution and degree of degenerative frontotemporal lesions and motor neuron disturbance were of various patterns. Ubiquitin‐positive and tau‐ and α‐synuclein negative intraneuronal inclusions and dystrophic neurites in extramotor cortices were observed in all cases. Furthermore, ubiquitin‐positive inclusions in lower motor neurons were found in all cases. The distribution pattern and density differed between neuronal inclusions and dystrophic neurites and correlated with clinicopathological phenotypes. Therefore, the ALS‐D spectrum may be broader than that previously recognized, extending to primary lateral sclerosis, atypical ALS and to atypical Pick's disease without Pick bodies. Further investigation is needed to determine the characteristics of the ubiquitinated component in ALS‐D." @default.
• W2079103750 created "2016-06-24" @default.
• W2079103750 creator A5013784750 @default.
• W2079103750 date "2004-02-26" @default.
• W2079103750 modified "2023-10-11" @default.
• W2079103750 title "Amyotrophic lateral sclerosis with dementia: The clinicopathological spectrum" @default.
• W2079103750 cites W118547715 @default.
• W2079103750 cites W141110513 @default.
• W2079103750 cites W1523390263 @default.
• W2079103750 cites W1589934608 @default.
• W2079103750 cites W159097492 @default.
• W2079103750 cites W181718899 @default.
• W2079103750 cites W1965328697 @default.
• W2079103750 cites W1968744160 @default.
• W2079103750 cites W1975186347 @default.
• W2079103750 cites W1975578769 @default.
• W2079103750 cites W1977379068 @default.
• W2079103750 cites W1979795566 @default.
• W2079103750 cites W1990461945 @default.
• W2079103750 cites W1991253128 @default.
• W2079103750 cites W1991890445 @default.
• W2079103750 cites W1996319685 @default.
• W2079103750 cites W2010528085 @default.
• W2079103750 cites W2011273849 @default.
• W2079103750 cites W2013214782 @default.
• W2079103750 cites W2018263680 @default.
• W2079103750 cites W2021330813 @default.
• W2079103750 cites W2031181999 @default.
• W2079103750 cites W2032523424 @default.
• W2079103750 cites W2035678859 @default.
• W2079103750 cites W2036123807 @default.
• W2079103750 cites W2037431629 @default.
• W2079103750 cites W2043445771 @default.
• W2079103750 cites W2045918603 @default.
• W2079103750 cites W2046659397 @default.
• W2079103750 cites W2052742260 @default.
• W2079103750 cites W2057801189 @default.
• W2079103750 cites W2060817112 @default.
• W2079103750 cites W2061495518 @default.
• W2079103750 cites W2071185298 @default.
• W2079103750 cites W2071602247 @default.
• W2079103750 cites W2090153807 @default.
• W2079103750 cites W2091694771 @default.
• W2079103750 cites W2092724166 @default.
• W2079103750 cites W2095362003 @default.
• W2079103750 cites W2107062472 @default.
• W2079103750 cites W2113159373 @default.
• W2079103750 cites W2123195968 @default.
• W2079103750 cites W2132623341 @default.
• W2079103750 cites W2133702405 @default.
• W2079103750 cites W2142151091 @default.
• W2079103750 cites W2146729934 @default.
• W2079103750 cites W2149927605 @default.
• W2079103750 cites W40595778 @default.
• W2079103750 cites W4255106309 @default.
• W2079103750 doi "https://doi.org/10.1111/j.1440-1789.2003.00544.x" @default.
• W2079103750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15068178" @default.
• W2079103750 hasPublicationYear "2004" @default.
• W2079103750 type Work @default.
• W2079103750 sameAs 2079103750 @default.
• W2079103750 citedByCount "92" @default.
• W2079103750 countsByYear W20791037502012 @default.
• W2079103750 countsByYear W20791037502013 @default.
• W2079103750 countsByYear W20791037502014 @default.
• W2079103750 countsByYear W20791037502015 @default.
• W2079103750 countsByYear W20791037502016 @default.
• W2079103750 countsByYear W20791037502017 @default.
• W2079103750 countsByYear W20791037502018 @default.
• W2079103750 countsByYear W20791037502019 @default.
• W2079103750 countsByYear W20791037502020 @default.
• W2079103750 countsByYear W20791037502021 @default.
• W2079103750 countsByYear W20791037502022 @default.
• W2079103750 countsByYear W20791037502023 @default.
• W2079103750 crossrefType "journal-article" @default.
• W2079103750 hasAuthorship W2079103750A5013784750 @default.
• W2079103750 hasConcept C113246987 @default.
• W2079103750 hasConcept C142724271 @default.
• W2079103750 hasConcept C15744967 @default.
• W2079103750 hasConcept C169760540 @default.
• W2079103750 hasConcept C202751555 @default.
• W2079103750 hasConcept C2776752467 @default.
• W2079103750 hasConcept C2776939681 @default.
• W2079103750 hasConcept C2777682930 @default.
• W2079103750 hasConcept C2777887643 @default.
• W2079103750 hasConcept C2778641062 @default.
• W2079103750 hasConcept C2779134260 @default.
• W2079103750 hasConcept C2779483572 @default.
• W2079103750 hasConcept C2779734285 @default.
• W2079103750 hasConcept C2780596555 @default.
• W2079103750 hasConcept C2780938664 @default.
• W2079103750 hasConcept C2781172350 @default.
• W2079103750 hasConcept C55493867 @default.
• W2079103750 hasConcept C71924100 @default.
• W2079103750 hasConcept C86803240 @default.
• W2079103750 hasConceptScore W2079103750C113246987 @default.
• W2079103750 hasConceptScore W2079103750C142724271 @default.
• W2079103750 hasConceptScore W2079103750C15744967 @default.
• W2079103750 hasConceptScore W2079103750C169760540 @default.

• next