Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079104514> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2079104514 endingPage "417" @default.
- W2079104514 startingPage "413" @default.
- W2079104514 abstract "The interleukin-1 (IL-1) signal is transduced through type I IL-1 receptor (IL-1RI). We have recently reported that lipopolysaccharide (LPS) upregulated IL-1RI mRNA expression in mouse liver in vivo and that IL-1 and IL-6 directly upregulated IL-1RI mRNA expression in primary cultured mouse hepatocytes. Glucocorticoid (GC) has been reported to increase IL-1 binding to the cell surface and the expression level of IL-1R mRNA in a variety of cell types. As serum GC level is elevated in an inflammatory response, we evaluated the role of GC in LPS-induced upregulation of IL-1RI mRNA in the mouse liver. When LPS was administered to adrenalectomized (ADX) mice, IL-1RI mRNA was upregulated at a level comparable to those of untreated or sham-operated mice. A high dose of dexamethasone (Dex), however, caused upregulation of the mRNA. When primary cultured mouse hepatocytes were treated with Dex, only a weak upregulation of IL-1RI mRNA was observed. However, Dex in combination with IL-1 or IL-6 markedly enhanced the IL-1RI mRNA expression. A marked upregulation of the mRNA was also induced by treatment with a combination of IL-1 and IL-6 in the absence of Dex, reflecting the observation in ADX mice. These results suggest that the upregulation of IL-1RI mRNA in response to LPS is induced by the interaction of IL-1 and IL-6 and that GC augments their effect." @default.
- W2079104514 created "2016-06-24" @default.
- W2079104514 creator A5027644779 @default.
- W2079104514 creator A5028473010 @default.
- W2079104514 creator A5040661425 @default.
- W2079104514 creator A5040769595 @default.
- W2079104514 creator A5044221680 @default.
- W2079104514 date "1997-07-01" @default.
- W2079104514 modified "2023-10-09" @default.
- W2079104514 title "Role of Glucocorticoid in the Upregulation of Type I Interleukin-1 Receptor mRNA Expression in Hepatocytes of Endotoxin-Administrated Mice" @default.
- W2079104514 cites W1546727913 @default.
- W2079104514 cites W1574330564 @default.
- W2079104514 cites W1894066899 @default.
- W2079104514 cites W1915518296 @default.
- W2079104514 cites W1974349360 @default.
- W2079104514 cites W1976887761 @default.
- W2079104514 cites W1997612555 @default.
- W2079104514 cites W2030407376 @default.
- W2079104514 cites W2049340737 @default.
- W2079104514 cites W2070893841 @default.
- W2079104514 cites W2073615621 @default.
- W2079104514 cites W2098870010 @default.
- W2079104514 cites W2104083541 @default.
- W2079104514 cites W2109652242 @default.
- W2079104514 cites W2145803099 @default.
- W2079104514 cites W2154746915 @default.
- W2079104514 cites W2161033554 @default.
- W2079104514 cites W4294216491 @default.
- W2079104514 doi "https://doi.org/10.1089/jir.1997.17.413" @default.
- W2079104514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9243374" @default.
- W2079104514 hasPublicationYear "1997" @default.
- W2079104514 type Work @default.
- W2079104514 sameAs 2079104514 @default.
- W2079104514 citedByCount "7" @default.
- W2079104514 crossrefType "journal-article" @default.
- W2079104514 hasAuthorship W2079104514A5027644779 @default.
- W2079104514 hasAuthorship W2079104514A5028473010 @default.
- W2079104514 hasAuthorship W2079104514A5040661425 @default.
- W2079104514 hasAuthorship W2079104514A5040769595 @default.
- W2079104514 hasAuthorship W2079104514A5044221680 @default.
- W2079104514 hasConcept C104317684 @default.
- W2079104514 hasConcept C105580179 @default.
- W2079104514 hasConcept C126322002 @default.
- W2079104514 hasConcept C127561419 @default.
- W2079104514 hasConcept C134018914 @default.
- W2079104514 hasConcept C153911025 @default.
- W2079104514 hasConcept C185592680 @default.
- W2079104514 hasConcept C2778690821 @default.
- W2079104514 hasConcept C2778754761 @default.
- W2079104514 hasConcept C2780401358 @default.
- W2079104514 hasConcept C2780841215 @default.
- W2079104514 hasConcept C55493867 @default.
- W2079104514 hasConcept C59493245 @default.
- W2079104514 hasConcept C71924100 @default.
- W2079104514 hasConcept C74172505 @default.
- W2079104514 hasConcept C86803240 @default.
- W2079104514 hasConceptScore W2079104514C104317684 @default.
- W2079104514 hasConceptScore W2079104514C105580179 @default.
- W2079104514 hasConceptScore W2079104514C126322002 @default.
- W2079104514 hasConceptScore W2079104514C127561419 @default.
- W2079104514 hasConceptScore W2079104514C134018914 @default.
- W2079104514 hasConceptScore W2079104514C153911025 @default.
- W2079104514 hasConceptScore W2079104514C185592680 @default.
- W2079104514 hasConceptScore W2079104514C2778690821 @default.
- W2079104514 hasConceptScore W2079104514C2778754761 @default.
- W2079104514 hasConceptScore W2079104514C2780401358 @default.
- W2079104514 hasConceptScore W2079104514C2780841215 @default.
- W2079104514 hasConceptScore W2079104514C55493867 @default.
- W2079104514 hasConceptScore W2079104514C59493245 @default.
- W2079104514 hasConceptScore W2079104514C71924100 @default.
- W2079104514 hasConceptScore W2079104514C74172505 @default.
- W2079104514 hasConceptScore W2079104514C86803240 @default.
- W2079104514 hasIssue "7" @default.
- W2079104514 hasLocation W20791045141 @default.
- W2079104514 hasLocation W20791045142 @default.
- W2079104514 hasOpenAccess W2079104514 @default.
- W2079104514 hasPrimaryLocation W20791045141 @default.
- W2079104514 hasRelatedWork W1578882671 @default.
- W2079104514 hasRelatedWork W1981540681 @default.
- W2079104514 hasRelatedWork W1991241272 @default.
- W2079104514 hasRelatedWork W2048445979 @default.
- W2079104514 hasRelatedWork W2119824100 @default.
- W2079104514 hasRelatedWork W2338237228 @default.
- W2079104514 hasRelatedWork W2359066614 @default.
- W2079104514 hasRelatedWork W2436275868 @default.
- W2079104514 hasRelatedWork W269771094 @default.
- W2079104514 hasRelatedWork W4318460051 @default.
- W2079104514 hasVolume "17" @default.
- W2079104514 isParatext "false" @default.
- W2079104514 isRetracted "false" @default.
- W2079104514 magId "2079104514" @default.
- W2079104514 workType "article" @default.