Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079105856> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2079105856 endingPage "e197" @default.
- W2079105856 startingPage "e196" @default.
- W2079105856 abstract "The obstructive sleep apnea syndrome (OSAS) is frequently associated with obesity, hypertension, diabetes and dyslipidemia and other cardiovascular risk factors. In addition, patients with untreated of OSAS have an increased cardio-vascular mortality and morbidity Apolipoprotein E (ApoE) plays an important role in the metabolism and transport of lipids. The three main isoforms (E2, E3, and E4) are coded by three common alleles (ε2, ε3, and ε4), resulting in six main genotypes: ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε3, ε3/ε4, and ε4/ε4. Presence of the APOE ε4 allele is also associated with HDL (High Density Lipoprotein). The aim of this study was to determine what is in our population the prevalence of different alleles of the ApoE gene, if there is an association of allele ε4 with OSAS and what is their contribution to metabolic syndrome. Cross-sectional study of 440 men patients. Mean age 54 ± 12 years (range 25–79 years), referred to the sleep unit for study.Written informed consent was obtained from all subjects for the extraction of genetic material, with exclusive analysis of the ApoE gene. Each patient has a clinical history reflecting metabolic and cardiovascular risk and medication in use. nthropometric data were recorded: weight, height, waist circumference and neck circumference. Determination of blood pressure (BP) at baseline. The study protocol included polysomnography (PSG) overnight in our sleep unit. Upon awakening, the BP was measure and simultaneously blood samples were collected, one for biochemical and other for the molecular biology laboratory, in order to extract DNA.The recorded variables were studied with the statistical program Statview. Parametric test was applied ANOVA for quantitative variables and chi-square (X2) for qualitative variables. Accepting a degree of significance of p < 0.05. The distribution of genotypes revealed that the prevalence of the ε3/ 3 allele was the most predominant (73.6% of cases), followed by the ε4 allele in 16.4, which is heterozygous in 15.4% (ε3/ 4) and 1% homozygous (ε4/ 4).The ε2 allele was the 10% off the population of the study. The ApoE ε4 patients have more severe OSAS with longer arterial oxygen desaturation during sleep, expressed by the T90. This genotype was associated with a statistically significant increase of inflammation markers and decreased melatonin. Also note that these patients has high tobacco consumption. In our population the distribution of the genotype correlates with is in the literature; there is an evidence of a relationship between ApoE ε4 genotype with moderate to severe sleep beathing disordered. sleep unit, Hospital General de Castellón." @default.
- W2079105856 created "2016-06-24" @default.
- W2079105856 creator A5029889488 @default.
- W2079105856 creator A5034034979 @default.
- W2079105856 creator A5034745894 @default.
- W2079105856 creator A5035329168 @default.
- W2079105856 creator A5046265091 @default.
- W2079105856 creator A5066328691 @default.
- W2079105856 date "2013-12-01" @default.
- W2079105856 modified "2023-09-23" @default.
- W2079105856 title "ApoE genotype and obstructive sleep apnea syndrome" @default.
- W2079105856 doi "https://doi.org/10.1016/j.sleep.2013.11.466" @default.
- W2079105856 hasPublicationYear "2013" @default.
- W2079105856 type Work @default.
- W2079105856 sameAs 2079105856 @default.
- W2079105856 citedByCount "0" @default.
- W2079105856 crossrefType "journal-article" @default.
- W2079105856 hasAuthorship W2079105856A5029889488 @default.
- W2079105856 hasAuthorship W2079105856A5034034979 @default.
- W2079105856 hasAuthorship W2079105856A5034745894 @default.
- W2079105856 hasAuthorship W2079105856A5035329168 @default.
- W2079105856 hasAuthorship W2079105856A5046265091 @default.
- W2079105856 hasAuthorship W2079105856A5066328691 @default.
- W2079105856 hasConcept C126322002 @default.
- W2079105856 hasConcept C134018914 @default.
- W2079105856 hasConcept C2776006263 @default.
- W2079105856 hasConcept C2778096610 @default.
- W2079105856 hasConcept C2778205975 @default.
- W2079105856 hasConcept C2779134260 @default.
- W2079105856 hasConcept C2780578515 @default.
- W2079105856 hasConcept C2781326671 @default.
- W2079105856 hasConcept C2908647359 @default.
- W2079105856 hasConcept C511355011 @default.
- W2079105856 hasConcept C57089818 @default.
- W2079105856 hasConcept C71924100 @default.
- W2079105856 hasConcept C99454951 @default.
- W2079105856 hasConceptScore W2079105856C126322002 @default.
- W2079105856 hasConceptScore W2079105856C134018914 @default.
- W2079105856 hasConceptScore W2079105856C2776006263 @default.
- W2079105856 hasConceptScore W2079105856C2778096610 @default.
- W2079105856 hasConceptScore W2079105856C2778205975 @default.
- W2079105856 hasConceptScore W2079105856C2779134260 @default.
- W2079105856 hasConceptScore W2079105856C2780578515 @default.
- W2079105856 hasConceptScore W2079105856C2781326671 @default.
- W2079105856 hasConceptScore W2079105856C2908647359 @default.
- W2079105856 hasConceptScore W2079105856C511355011 @default.
- W2079105856 hasConceptScore W2079105856C57089818 @default.
- W2079105856 hasConceptScore W2079105856C71924100 @default.
- W2079105856 hasConceptScore W2079105856C99454951 @default.
- W2079105856 hasLocation W20791058561 @default.
- W2079105856 hasOpenAccess W2079105856 @default.
- W2079105856 hasPrimaryLocation W20791058561 @default.
- W2079105856 hasRelatedWork W1755705937 @default.
- W2079105856 hasRelatedWork W1762024076 @default.
- W2079105856 hasRelatedWork W1906591852 @default.
- W2079105856 hasRelatedWork W2043587974 @default.
- W2079105856 hasRelatedWork W2045961483 @default.
- W2079105856 hasRelatedWork W2055092536 @default.
- W2079105856 hasRelatedWork W2073221700 @default.
- W2079105856 hasRelatedWork W2090656314 @default.
- W2079105856 hasRelatedWork W2102691551 @default.
- W2079105856 hasRelatedWork W2103707689 @default.
- W2079105856 hasRelatedWork W2231999384 @default.
- W2079105856 hasRelatedWork W2320297673 @default.
- W2079105856 hasRelatedWork W2355502877 @default.
- W2079105856 hasRelatedWork W2408899696 @default.
- W2079105856 hasRelatedWork W2412506350 @default.
- W2079105856 hasRelatedWork W2957914896 @default.
- W2079105856 hasRelatedWork W3011574984 @default.
- W2079105856 hasRelatedWork W3030083095 @default.
- W2079105856 hasRelatedWork W3032167662 @default.
- W2079105856 hasRelatedWork W3201889243 @default.
- W2079105856 hasVolume "14" @default.
- W2079105856 isParatext "false" @default.
- W2079105856 isRetracted "false" @default.
- W2079105856 magId "2079105856" @default.
- W2079105856 workType "article" @default.