FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079109797> ?p ?o ?g. }

• W2079109797 endingPage "e1042" @default.
• W2079109797 startingPage "e1042" @default.
• W2079109797 abstract "Background In areas endemic for visceral leishmaniasis (VL), a large number of infected individuals mount a protective cellular immune response and remain asymptomatic carriers. We propose an interferon-gamma release assay (IFN-γRA) as a novel marker for latent L. donovani infection. Methods and Findings We modified a commercial kit (QuantiFERON) evaluating five different leishmania-specific antigens; H2B, H2B-PSA2, H2B-Lepp12, crude soluble antigen (CSA) and soluble leishmania antigen (SLA) from L. donovani with the aim to detect the cell-mediated immune response in VL. We evaluated the assay on venous blood samples of active VL patients (n = 13), cured VL patients (n = 15), non-endemic healthy controls (n = 11) and healthy endemic controls (n = 19). The assay based on SLA had a sensitivity of 80% (95% CI = 54.81–92.95) and specificity of 100% (95% CI = 74.12–100). Conclusion Our findings suggest that a whole-blood SLA-based QuantiFERON assay can be used to measure the cell-mediated immune response in L. donovani infection. The positive IFN-γ response to stimulation with leishmania antigen in patients with active VL was contradictory to the conventional finding of a non-proliferative antigen-specific response of peripheral blood mononuclear cells and needs further research." @default.
• W2079109797 created "2016-06-24" @default.
• W2079109797 creator A5005151809 @default.
• W2079109797 creator A5023875949 @default.
• W2079109797 creator A5027677067 @default.
• W2079109797 creator A5062735205 @default.
• W2079109797 creator A5090360946 @default.
• W2079109797 date "2011-04-19" @default.
• W2079109797 modified "2023-10-16" @default.
• W2079109797 title "Interferon-Gamma Release Assay (Modified QuantiFERON) as a Potential Marker of Infection for Leishmania donovani, a Proof of Concept Study" @default.
• W2079109797 cites W1493993200 @default.
• W2079109797 cites W1880476205 @default.
• W2079109797 cites W1932819187 @default.
• W2079109797 cites W2016570101 @default.
• W2079109797 cites W2029921922 @default.
• W2079109797 cites W2056689994 @default.
• W2079109797 cites W2074642626 @default.
• W2079109797 cites W2091246270 @default.
• W2079109797 cites W2097973390 @default.
• W2079109797 cites W2102777134 @default.
• W2079109797 cites W2106378467 @default.
• W2079109797 cites W2137891369 @default.
• W2079109797 cites W2157018125 @default.
• W2079109797 cites W2157939920 @default.
• W2079109797 cites W2172204408 @default.
• W2079109797 cites W2261062469 @default.
• W2079109797 doi "https://doi.org/10.1371/journal.pntd.0001042" @default.
• W2079109797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3079582" @default.
• W2079109797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21526219" @default.
• W2079109797 hasPublicationYear "2011" @default.
• W2079109797 type Work @default.
• W2079109797 sameAs 2079109797 @default.
• W2079109797 citedByCount "45" @default.
• W2079109797 countsByYear W20791097972012 @default.
• W2079109797 countsByYear W20791097972013 @default.
• W2079109797 countsByYear W20791097972014 @default.
• W2079109797 countsByYear W20791097972015 @default.
• W2079109797 countsByYear W20791097972016 @default.
• W2079109797 countsByYear W20791097972017 @default.
• W2079109797 countsByYear W20791097972018 @default.
• W2079109797 countsByYear W20791097972019 @default.
• W2079109797 countsByYear W20791097972020 @default.
• W2079109797 countsByYear W20791097972021 @default.
• W2079109797 countsByYear W20791097972022 @default.
• W2079109797 crossrefType "journal-article" @default.
• W2079109797 hasAuthorship W2079109797A5005151809 @default.
• W2079109797 hasAuthorship W2079109797A5023875949 @default.
• W2079109797 hasAuthorship W2079109797A5027677067 @default.
• W2079109797 hasAuthorship W2079109797A5062735205 @default.
• W2079109797 hasAuthorship W2079109797A5090360946 @default.
• W2079109797 hasBestOaLocation W20791097971 @default.
• W2079109797 hasConcept C136764020 @default.
• W2079109797 hasConcept C137061746 @default.
• W2079109797 hasConcept C142724271 @default.
• W2079109797 hasConcept C147483822 @default.
• W2079109797 hasConcept C202751555 @default.
• W2079109797 hasConcept C203014093 @default.
• W2079109797 hasConcept C2776555147 @default.
• W2079109797 hasConcept C2776763545 @default.
• W2079109797 hasConcept C2777975735 @default.
• W2079109797 hasConcept C2778689377 @default.
• W2079109797 hasConcept C2779806340 @default.
• W2079109797 hasConcept C2780841837 @default.
• W2079109797 hasConcept C2781069245 @default.
• W2079109797 hasConcept C2781092759 @default.
• W2079109797 hasConcept C2781333301 @default.
• W2079109797 hasConcept C41008148 @default.
• W2079109797 hasConcept C55493867 @default.
• W2079109797 hasConcept C71924100 @default.
• W2079109797 hasConcept C71928629 @default.
• W2079109797 hasConcept C86803240 @default.
• W2079109797 hasConcept C8891405 @default.
• W2079109797 hasConceptScore W2079109797C136764020 @default.
• W2079109797 hasConceptScore W2079109797C137061746 @default.
• W2079109797 hasConceptScore W2079109797C142724271 @default.
• W2079109797 hasConceptScore W2079109797C147483822 @default.
• W2079109797 hasConceptScore W2079109797C202751555 @default.
• W2079109797 hasConceptScore W2079109797C203014093 @default.
• W2079109797 hasConceptScore W2079109797C2776555147 @default.
• W2079109797 hasConceptScore W2079109797C2776763545 @default.
• W2079109797 hasConceptScore W2079109797C2777975735 @default.
• W2079109797 hasConceptScore W2079109797C2778689377 @default.
• W2079109797 hasConceptScore W2079109797C2779806340 @default.
• W2079109797 hasConceptScore W2079109797C2780841837 @default.
• W2079109797 hasConceptScore W2079109797C2781069245 @default.
• W2079109797 hasConceptScore W2079109797C2781092759 @default.
• W2079109797 hasConceptScore W2079109797C2781333301 @default.
• W2079109797 hasConceptScore W2079109797C41008148 @default.
• W2079109797 hasConceptScore W2079109797C55493867 @default.
• W2079109797 hasConceptScore W2079109797C71924100 @default.
• W2079109797 hasConceptScore W2079109797C71928629 @default.
• W2079109797 hasConceptScore W2079109797C86803240 @default.
• W2079109797 hasConceptScore W2079109797C8891405 @default.
• W2079109797 hasIssue "4" @default.
• W2079109797 hasLocation W20791097971 @default.
• W2079109797 hasLocation W20791097972 @default.
• W2079109797 hasLocation W20791097973 @default.
• W2079109797 hasLocation W20791097974 @default.

• next