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- W2079112084 abstract "High mobility group box 1 (HMGB1), a 30 kDa nuclear and cytosolic protein widely studied as a transcription factor and growth factor, has recently been identified as a cytokine mediator of lethal systemic inflammation (e.g. endotoxaemia and sepsis), arthritis and local inflammation. It is released by activated macrophages, and serum levels increase significantly during endotoxaemia, sepsis and arthritis with significant delayed kinetics in comparison with tumour necrosis factor (TNF) and interleukin-1beta. Recently identified biological activities of HMGB1 include activation of macrophages/monocytes to release proinflammatory cytokines, upregulation of endothelial adhesion molecules, stimulation of epithelial cell barrier failure, and mediation of fever and anorexia. Passive immunization with anti-HMGB1 antibodies confers significant protection against lethal endotoxaemia, sepsis, arthritis and lipopolysaccharide-induced acute lung injury, even when antibody administration is delayed until after the early TNF responses have resolved. Strategies to inhibit HMGB1 activity and release are being investigated in these and other preclinical models of acute and chronic inflammation." @default.
- W2079112084 created "2016-06-24" @default.
- W2079112084 creator A5010156954 @default.
- W2079112084 creator A5075492017 @default.
- W2079112084 creator A5077906192 @default.
- W2079112084 date "2004-02-10" @default.
- W2079112084 modified "2023-10-14" @default.
- W2079112084 title "Extracellular role of HMGB1 in inflammation and sepsis" @default.
- W2079112084 cites W1511842456 @default.
- W2079112084 cites W1514452974 @default.
- W2079112084 cites W1519947104 @default.
- W2079112084 cites W1524615273 @default.
- W2079112084 cites W1541957757 @default.
- W2079112084 cites W155031556 @default.
- W2079112084 cites W1574734561 @default.
- W2079112084 cites W1579897694 @default.
- W2079112084 cites W1590156932 @default.
- W2079112084 cites W1655974196 @default.
- W2079112084 cites W1946578458 @default.
- W2079112084 cites W1968713831 @default.
- W2079112084 cites W1970456030 @default.
- W2079112084 cites W1972293204 @default.
- W2079112084 cites W1983379130 @default.
- W2079112084 cites W1984270065 @default.
- W2079112084 cites W1988871099 @default.
- W2079112084 cites W1989658278 @default.
- W2079112084 cites W1997054462 @default.
- W2079112084 cites W2001822918 @default.
- W2079112084 cites W2004013297 @default.
- W2079112084 cites W2004266769 @default.
- W2079112084 cites W2005640704 @default.
- W2079112084 cites W2006515559 @default.
- W2079112084 cites W2009550948 @default.
- W2079112084 cites W2011511497 @default.
- W2079112084 cites W2016370501 @default.
- W2079112084 cites W2020320857 @default.
- W2079112084 cites W2021653739 @default.
- W2079112084 cites W2023532695 @default.
- W2079112084 cites W2026885016 @default.
- W2079112084 cites W2032559458 @default.
- W2079112084 cites W2034311142 @default.
- W2079112084 cites W2038434279 @default.
- W2079112084 cites W2042423070 @default.
- W2079112084 cites W2047002683 @default.
- W2079112084 cites W2049670226 @default.
- W2079112084 cites W2054605399 @default.
- W2079112084 cites W2055033922 @default.
- W2079112084 cites W2055744632 @default.
- W2079112084 cites W2059217150 @default.
- W2079112084 cites W2062568081 @default.
- W2079112084 cites W2062824264 @default.
- W2079112084 cites W2065427271 @default.
- W2079112084 cites W2066689854 @default.
- W2079112084 cites W2067853554 @default.
- W2079112084 cites W2070713758 @default.
- W2079112084 cites W2071256672 @default.
- W2079112084 cites W2080126967 @default.
- W2079112084 cites W2084557685 @default.
- W2079112084 cites W2090521351 @default.
- W2079112084 cites W2090833444 @default.
- W2079112084 cites W2097391811 @default.
- W2079112084 cites W2103224375 @default.
- W2079112084 cites W2109591730 @default.
- W2079112084 cites W2114103294 @default.
- W2079112084 cites W2118872783 @default.
- W2079112084 cites W2125751904 @default.
- W2079112084 cites W2128426645 @default.
- W2079112084 cites W2135374161 @default.
- W2079112084 cites W2141685355 @default.
- W2079112084 cites W2146807706 @default.
- W2079112084 cites W2147426561 @default.
- W2079112084 cites W2152058417 @default.
- W2079112084 cites W2153145727 @default.
- W2079112084 cites W2157404235 @default.
- W2079112084 cites W2160369507 @default.
- W2079112084 cites W2161619169 @default.
- W2079112084 cites W2164714222 @default.
- W2079112084 cites W2168514472 @default.
- W2079112084 cites W2168643298 @default.
- W2079112084 cites W2170546457 @default.
- W2079112084 cites W2171028311 @default.
- W2079112084 cites W2321427723 @default.
- W2079112084 cites W2339656438 @default.
- W2079112084 cites W2344995500 @default.
- W2079112084 cites W2892793769 @default.
- W2079112084 cites W3150483150 @default.
- W2079112084 cites W4233578116 @default.
- W2079112084 cites W4237911804 @default.
- W2079112084 cites W4249072368 @default.
- W2079112084 cites W4254228157 @default.
- W2079112084 cites W4254904290 @default.
- W2079112084 cites W4295965450 @default.
- W2079112084 doi "https://doi.org/10.1111/j.1365-2796.2003.01302.x" @default.
- W2079112084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14871456" @default.
- W2079112084 hasPublicationYear "2004" @default.
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