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- W2079118009 endingPage "487" @default.
- W2079118009 startingPage "473" @default.
- W2079118009 abstract "HIV-1 entry begins with viral envelope glycoprotein gp120 interacting with host-cell CD4 and an entry coreceptor (mainly chemokine receptors CCR5 or CXCR4). Inhibitors of particular coreceptors are being developed in order to exploit this step of cellular infection. However, effectiveness of these drugs requires matching of the administered therapeutic to coreceptor use by the viral variants infecting each patient. Patient viruses may use only CCR5 (R5), only CXCR4 (X4) or both (D/M). Most patients in early disease have R5 variants, with the presence of X4 variants increasing as disease progresses; the infecting subtype also affects the prevalence of X4 variants. Phenotypic, genotypic and clinical trial tests are in use to determine coreceptor utilization by HIV-1 variants, termed tropism, and to predict the response to entry inhibitors. Maraviroc is the only approved entry-coreceptor inhibitor and inhibits CCR5-gp120 interaction. Clinical trials of maraviroc in specific patient subgroups are elucidating the drug's role in contemporary clinical practice. Treatment failure to this and other CCR5 inhibitors has been shown to result from either outgrowth of X4 variants or through resistance mutations leading to R5 variants that are able to enter cells using drug-bound CCR5; thus, new entry inhibitors seek to circumvent this mechanism of resistance." @default.
- W2079118009 created "2016-06-24" @default.
- W2079118009 creator A5003058226 @default.
- W2079118009 creator A5009484606 @default.
- W2079118009 date "2014-03-17" @default.
- W2079118009 modified "2023-10-16" @default.
- W2079118009 title "Effect of HIV-1 subtype and tropism on treatment with chemokine coreceptor entry inhibitors; overview of viral entry inhibition" @default.
- W2079118009 cites W1486807506 @default.
- W2079118009 cites W1526468136 @default.
- W2079118009 cites W1598711637 @default.
- W2079118009 cites W1607005809 @default.
- W2079118009 cites W1623426438 @default.
- W2079118009 cites W1723922714 @default.
- W2079118009 cites W1900729316 @default.
- W2079118009 cites W1922162046 @default.
- W2079118009 cites W1945834141 @default.
- W2079118009 cites W1953735714 @default.
- W2079118009 cites W1965071100 @default.
- W2079118009 cites W1965161223 @default.
- W2079118009 cites W1965665268 @default.
- W2079118009 cites W1966092083 @default.
- W2079118009 cites W1967971783 @default.
- W2079118009 cites W1969779756 @default.
- W2079118009 cites W1971144240 @default.
- W2079118009 cites W1974785190 @default.
- W2079118009 cites W1975223729 @default.
- W2079118009 cites W1976466060 @default.
- W2079118009 cites W1976819270 @default.
- W2079118009 cites W1977265260 @default.
- W2079118009 cites W1977984938 @default.
- W2079118009 cites W1978237106 @default.
- W2079118009 cites W1982463711 @default.
- W2079118009 cites W1982498479 @default.
- W2079118009 cites W1983800253 @default.
- W2079118009 cites W1985613448 @default.
- W2079118009 cites W1985722970 @default.
- W2079118009 cites W1986501793 @default.
- W2079118009 cites W1986993888 @default.
- W2079118009 cites W1987600691 @default.
- W2079118009 cites W1991027199 @default.
- W2079118009 cites W1993270674 @default.
- W2079118009 cites W1993941418 @default.
- W2079118009 cites W1994778793 @default.
- W2079118009 cites W1996666478 @default.
- W2079118009 cites W1998383398 @default.
- W2079118009 cites W1998942821 @default.
- W2079118009 cites W1999071481 @default.
- W2079118009 cites W2002271571 @default.
- W2079118009 cites W2002574877 @default.
- W2079118009 cites W2002702640 @default.
- W2079118009 cites W2002915433 @default.
- W2079118009 cites W2003240710 @default.
- W2079118009 cites W2005394493 @default.
- W2079118009 cites W2005914731 @default.
- W2079118009 cites W2006426797 @default.
- W2079118009 cites W2007021820 @default.
- W2079118009 cites W2010452637 @default.
- W2079118009 cites W2012510536 @default.
- W2079118009 cites W2014451131 @default.
- W2079118009 cites W2016180326 @default.
- W2079118009 cites W2016309641 @default.
- W2079118009 cites W2017070671 @default.
- W2079118009 cites W2021889991 @default.
- W2079118009 cites W2021905358 @default.
- W2079118009 cites W2024353108 @default.
- W2079118009 cites W2026444780 @default.
- W2079118009 cites W2032091598 @default.
- W2079118009 cites W2036798094 @default.
- W2079118009 cites W2036920675 @default.
- W2079118009 cites W2037793240 @default.
- W2079118009 cites W2038063067 @default.
- W2079118009 cites W2038194012 @default.
- W2079118009 cites W2040186892 @default.
- W2079118009 cites W2042141726 @default.
- W2079118009 cites W2044676910 @default.
- W2079118009 cites W2045524299 @default.
- W2079118009 cites W2046557258 @default.
- W2079118009 cites W2047059663 @default.
- W2079118009 cites W2058252938 @default.
- W2079118009 cites W2058931697 @default.
- W2079118009 cites W2062044947 @default.
- W2079118009 cites W2065832117 @default.
- W2079118009 cites W2066480278 @default.
- W2079118009 cites W2068547302 @default.
- W2079118009 cites W2070990188 @default.
- W2079118009 cites W2075064825 @default.
- W2079118009 cites W2075322672 @default.
- W2079118009 cites W2077873821 @default.
- W2079118009 cites W2078300006 @default.
- W2079118009 cites W2081321475 @default.
- W2079118009 cites W2081958224 @default.
- W2079118009 cites W2082116017 @default.
- W2079118009 cites W2082737563 @default.
- W2079118009 cites W2083893733 @default.
- W2079118009 cites W2086044183 @default.
- W2079118009 cites W2086572129 @default.
- W2079118009 cites W2087320819 @default.
- W2079118009 cites W2091132204 @default.