Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079120043> ?p ?o ?g. }
- W2079120043 endingPage "188" @default.
- W2079120043 startingPage "176" @default.
- W2079120043 abstract "The olfactory epithelium of the mouse has many properties that make it an ideal system for studying the molecular regulation of neurogenesis. We have used a combination of in vitro and in vivo approaches to identify three distinct stages of neuronal progenitors in the olfactory receptor neuron lineage. The neuronal stem cell, which is ultimately responsible for continual neuron renewal in this system, gives rise to a transit amplifying progenitor identified by its expression of a transcription factor, MASH1. The MASH1-expressing progenitor gives rise to a second transit amplifying progenitor, the Immediate Neuronal Precursor, which is distinct from the stem cell and MASH1-expressing progenitor, and gives rise quantitatively to olfactory receptor neurons. Regulation of progenitor cell proliferation and differentiation occurs at each of these three cell stages, and growth factors of the fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) families appear to play particularly important roles in these processes. Analyses of the actions of FGFs and BMPs reveal that negative signaling plays at least as important a role as positive signaling in the regulation of olfactory neurogenesis." @default.
- W2079120043 created "2016-06-24" @default.
- W2079120043 creator A5020125811 @default.
- W2079120043 creator A5037540828 @default.
- W2079120043 creator A5048939286 @default.
- W2079120043 creator A5050150844 @default.
- W2079120043 creator A5054616509 @default.
- W2079120043 creator A5054628529 @default.
- W2079120043 creator A5062331307 @default.
- W2079120043 date "2002-07-23" @default.
- W2079120043 modified "2023-09-30" @default.
- W2079120043 title "Progenitor cells of the olfactory receptor neuron lineage" @default.
- W2079120043 cites W120093904 @default.
- W2079120043 cites W142333331 @default.
- W2079120043 cites W1527331090 @default.
- W2079120043 cites W1537079504 @default.
- W2079120043 cites W1542222934 @default.
- W2079120043 cites W1558226015 @default.
- W2079120043 cites W1573258215 @default.
- W2079120043 cites W1589139546 @default.
- W2079120043 cites W1765469392 @default.
- W2079120043 cites W1826524642 @default.
- W2079120043 cites W1845077221 @default.
- W2079120043 cites W1922697055 @default.
- W2079120043 cites W1965884916 @default.
- W2079120043 cites W1968019641 @default.
- W2079120043 cites W1972320412 @default.
- W2079120043 cites W1978177808 @default.
- W2079120043 cites W1982555416 @default.
- W2079120043 cites W1983133453 @default.
- W2079120043 cites W1988027093 @default.
- W2079120043 cites W1989867073 @default.
- W2079120043 cites W1992559178 @default.
- W2079120043 cites W1999756818 @default.
- W2079120043 cites W2001534443 @default.
- W2079120043 cites W2002353171 @default.
- W2079120043 cites W2004090362 @default.
- W2079120043 cites W2004836530 @default.
- W2079120043 cites W2007081540 @default.
- W2079120043 cites W2015091248 @default.
- W2079120043 cites W2019997163 @default.
- W2079120043 cites W2021951330 @default.
- W2079120043 cites W2023928947 @default.
- W2079120043 cites W2023930954 @default.
- W2079120043 cites W2027727992 @default.
- W2079120043 cites W2029675195 @default.
- W2079120043 cites W2034750934 @default.
- W2079120043 cites W2038639188 @default.
- W2079120043 cites W2039119477 @default.
- W2079120043 cites W2056330526 @default.
- W2079120043 cites W2064520670 @default.
- W2079120043 cites W2067315256 @default.
- W2079120043 cites W2067884021 @default.
- W2079120043 cites W2070897110 @default.
- W2079120043 cites W2076425777 @default.
- W2079120043 cites W2079666001 @default.
- W2079120043 cites W2080738247 @default.
- W2079120043 cites W2081327471 @default.
- W2079120043 cites W2081858421 @default.
- W2079120043 cites W2082740213 @default.
- W2079120043 cites W2083550358 @default.
- W2079120043 cites W2083723382 @default.
- W2079120043 cites W2087126781 @default.
- W2079120043 cites W2087599837 @default.
- W2079120043 cites W2089269195 @default.
- W2079120043 cites W2093452639 @default.
- W2079120043 cites W2098867949 @default.
- W2079120043 cites W2112731799 @default.
- W2079120043 cites W2113002082 @default.
- W2079120043 cites W2115340713 @default.
- W2079120043 cites W2119896129 @default.
- W2079120043 cites W2123957194 @default.
- W2079120043 cites W2124026564 @default.
- W2079120043 cites W2125396289 @default.
- W2079120043 cites W2128678520 @default.
- W2079120043 cites W2128737197 @default.
- W2079120043 cites W2130174790 @default.
- W2079120043 cites W2138302361 @default.
- W2079120043 cites W2138903858 @default.
- W2079120043 cites W2139103260 @default.
- W2079120043 cites W2139949950 @default.
- W2079120043 cites W2148459495 @default.
- W2079120043 cites W2149457406 @default.
- W2079120043 cites W2151792462 @default.
- W2079120043 cites W2152185266 @default.
- W2079120043 cites W2158499654 @default.
- W2079120043 cites W2184436455 @default.
- W2079120043 cites W2286913336 @default.
- W2079120043 cites W4239431608 @default.
- W2079120043 doi "https://doi.org/10.1002/jemt.10147" @default.
- W2079120043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12203696" @default.
- W2079120043 hasPublicationYear "2002" @default.
- W2079120043 type Work @default.
- W2079120043 sameAs 2079120043 @default.
- W2079120043 citedByCount "131" @default.
- W2079120043 countsByYear W20791200432012 @default.
- W2079120043 countsByYear W20791200432013 @default.
- W2079120043 countsByYear W20791200432014 @default.