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- W2079120705 abstract "A synthesis of α-aminophosphonate analogs of polyoxins, termed phosphonoxin C1, C2, and C3, has been achieved. The key step was the addition of lithium dimethyl phosphite to the aldehyde of a protected threose derivative. α-Hydroxyphosphonate analogs C4 and C5 were also obtained by taking advantage of an unprecedented conversion of an azide to hydroxyl during treatment with hydrogen on palladium on carbon. The resulting phosphonoxin C5 inhibited the growth of an intestinal protozoan, Giardia lamblia, at low micromolar concentration." @default.
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- W2079120705 date "2010-09-21" @default.
- W2079120705 modified "2023-10-18" @default.
- W2079120705 title "Phosphonoxins III: Synthesis of α-Aminophosphonate Analogs of Antifungal Polyoxins with Anti-<i>Giardia</i> Activity" @default.
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- W2079120705 doi "https://doi.org/10.1021/ol101913t" @default.
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