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- W2079121293 abstract "Significance This article concerns the control of competence for bacterial genetic transformation. Competence is transient in the human pathogen Streptococcus pneumoniae , involving the specific expression of ∼100 genes that are turned ON suddenly and OFF almost as abruptly. Although the mechanism rendering all cells in a culture simultaneously competent is well understood, how competence stops has remained unknown. Here, we unravel the mechanism of shut-off, describing the discovery that a key recombination protein, DprA, exerts a negative control on competence through direct, physical interaction with the master regulator of competence, the response regulator ComE, to abolish transcription from ComE-activated promoters." @default.
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- W2079121293 date "2012-02-07" @default.
- W2079121293 modified "2023-10-12" @default.
- W2079121293 title "Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence" @default.
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- W2079121293 doi "https://doi.org/10.1073/pnas.1219868110" @default.
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