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- W2079122560 abstract "The cell integrity pathway of Saccharomyces cerevisiae monitors cell wall remodelling during growth and differentiation. Additionally, this pathway responds to environmental stresses that challenge the integrity of the cell wall. We conducted a genome-wide survey of genes whose expression was altered in response to activation of Mpk1/Slt2, the MAP kinase, under the control of cell integrity signalling. We identified 25 genes whose regulation was altered by Mpk1 activity. Among these, 20 were positively regulated by Mpk1, and five were negatively regulated. Most of the genes identified encode either known or suspected cell wall proteins or enzymes involved in cell wall biogenesis. These include glycosyl-phosphatidylinositol (GPI) proteins, members of the Pir family of cell wall proteins, Mpk1 itself and others. All of the regulation detected was mediated by the Rlm1 transcription factor, a MADS-box protein that is phosphorylated and activated by Mpk1, but for which no transcriptional targets had been identified. A similar pattern of regulation was observed when cell integrity signalling was induced by environmental stress (i.e. temperature upshift)." @default.
- W2079122560 created "2016-06-24" @default.
- W2079122560 creator A5056383381 @default.
- W2079122560 creator A5057353691 @default.
- W2079122560 date "1999-12-01" @default.
- W2079122560 modified "2023-10-13" @default.
- W2079122560 title "Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway" @default.
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- W2079122560 doi "https://doi.org/10.1046/j.1365-2958.1999.01667.x" @default.
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