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- W2079130186 endingPage "310" @default.
- W2079130186 startingPage "287" @default.
- W2079130186 abstract "A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared to DNA. PNAs are resistant to nucleases and proteases and have a low affinity for proteins. These properties make PNAs an attractive agent for biological and medical applications. To improve the antisense and antigene properties of PNAs, many backbone modifications of PNAs have been explored under the concept of preorganization. This review focuses on chiral PNAs bearing a substituent in the N-(2-aminoethyl)glycine backbone. Syntheses, properties, and applications of chiral PNAs are described." @default.
- W2079130186 created "2016-06-24" @default.
- W2079130186 creator A5012171799 @default.
- W2079130186 creator A5069137890 @default.
- W2079130186 date "2012-12-27" @default.
- W2079130186 modified "2023-10-16" @default.
- W2079130186 title "Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone" @default.
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