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- W2079132877 endingPage "5979" @default.
- W2079132877 startingPage "5972" @default.
- W2079132877 abstract "Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic, prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size present in infectious microorganisms) is a potent, natural pathophysiologic activator of the contact pathway of blood clotting. Medium-chain polyphosphate (of the size secreted from activated human platelets) accelerates factor V activation, completely abrogates the anticoagulant function of tissue factor pathway inhibitor, enhances fibrin clot structure, and greatly accelerates factor XI activation by thrombin. Polyphosphate may have utility as a hemostatic agent, whereas antagonists of polyphosphate may function as novel antithrombotic/anti-inflammatory agents. The detailed molecular mechanisms by which polyphosphate modulates blood clotting reactions remain to be elucidated." @default.
- W2079132877 created "2016-06-24" @default.
- W2079132877 creator A5060771191 @default.
- W2079132877 creator A5080935177 @default.
- W2079132877 creator A5088129092 @default.
- W2079132877 date "2012-06-21" @default.
- W2079132877 modified "2023-10-14" @default.
- W2079132877 title "Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation" @default.
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