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• W2079133394 startingPage "758" @default.
• W2079133394 abstract "Summary: Purpose: Hippocampal CA3 neurons of spontaneously epileptic rats (SER; zi/zi, tm/tm ), which show both absence‐like seizures and tonic convulsions, exhibit a long‐lasting depolarization shift with repetitive firing with a single stimulation of mossy fibers. Therefore a whole‐cell patch‐clamp study using temporarily dissociated hippocampal CA3 neurons from SER was performed to elucidate whether such abnormal excitability was due to abnormalities in voltage‐dependent Ca 2+ channels (VDCCs). Methods: Hippocampal CA3 neurons were temporarily dissociated with enzymatic and mechanical treatments. In a voltage‐clamp mode with whole‐cell recording, depolarizing step pulses were applied to induce Ca 2+ currents in the presence of tetrodotoxin and tetraethylammonium. Results: The threshold level of the Ca 2+ current induced by depolarizing pulses was found to be lower in hippocampal CA3 neurons of SER compared with those of control Wistar rats. In addition, the Ca 2+ current peak amplitude was greater, and decay of the current was weaker in CA3 neurons of SER than in those of normal Wistar rats. Conclusions: These findings suggest that enhancements of Ca 2+ influx into hippocampal CA3 neurons due to the easier activation properties of VDCCs, as well as a decrease in decay, are involved in SER epileptic seizures." @default.
• W2079133394 created "2016-06-24" @default.
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• W2079133394 date "2007-03-13" @default.
• W2079133394 modified "2023-10-17" @default.
• W2079133394 title "Voltage-dependent Calcium Channel Abnormalities in Hippocampal CA3 Neurons of Spontaneously Epileptic Rats" @default.
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• W2079133394 doi "https://doi.org/10.1111/j.1528-1167.2007.00957.x" @default.
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