Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079134736> ?p ?o ?g. }
- W2079134736 endingPage "238" @default.
- W2079134736 startingPage "229" @default.
- W2079134736 abstract "Premature birth is a significant economic and public health burden, and its incidence is rising. Periventricular leukomalacia (PVL) is the predominant form of brain injury in premature infants and the leading cause of cerebral palsy. PVL is characterized by selective white-matter damage with prominent oligodendroglial injury. The maturation-dependent vulnerability of developing and premyelinating oligodendrocytes to excitotoxic, oxidative, and inflammatory forms of injury is a major factor in the pathogenesis of PVL. Recent studies using mouse models of PVL reveal that synapses between axons and developing oligodendrocytes are quickly and profoundly damaged in immature white matter. Axon-glia synapses are highly vulnerable to white-matter injury in the developing brain, and the loss of synapses between axons and premyelinating oligodendrocytes occurs before any cellular loss in the immature white matter. Microglial activation and astrogliosis play important roles in triggering white-matter injury. Impairment of white-matter development and function in the neonatal period contributes critically to functional and behavioral deficits. Preservation of the integrity of the white matter is likely key in the treatment of PVL and subsequent neurological consequences and disabilities." @default.
- W2079134736 created "2016-06-24" @default.
- W2079134736 creator A5001959448 @default.
- W2079134736 creator A5032012066 @default.
- W2079134736 creator A5050051706 @default.
- W2079134736 creator A5068093752 @default.
- W2079134736 date "2013-02-28" @default.
- W2079134736 modified "2023-09-25" @default.
- W2079134736 title "Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury" @default.
- W2079134736 cites W123675495 @default.
- W2079134736 cites W1562902980 @default.
- W2079134736 cites W1583433785 @default.
- W2079134736 cites W1740130847 @default.
- W2079134736 cites W1869836674 @default.
- W2079134736 cites W1896545635 @default.
- W2079134736 cites W1928529925 @default.
- W2079134736 cites W1972442492 @default.
- W2079134736 cites W1972508873 @default.
- W2079134736 cites W1978924462 @default.
- W2079134736 cites W1981236246 @default.
- W2079134736 cites W1985757554 @default.
- W2079134736 cites W1987885030 @default.
- W2079134736 cites W1989550899 @default.
- W2079134736 cites W1991090438 @default.
- W2079134736 cites W1995874521 @default.
- W2079134736 cites W2001888569 @default.
- W2079134736 cites W2032741148 @default.
- W2079134736 cites W2049224825 @default.
- W2079134736 cites W2050989030 @default.
- W2079134736 cites W2053440290 @default.
- W2079134736 cites W2056007987 @default.
- W2079134736 cites W2062516218 @default.
- W2079134736 cites W2062793260 @default.
- W2079134736 cites W2063272984 @default.
- W2079134736 cites W2063320607 @default.
- W2079134736 cites W2072261330 @default.
- W2079134736 cites W2075319342 @default.
- W2079134736 cites W2077950980 @default.
- W2079134736 cites W2082580274 @default.
- W2079134736 cites W2089249713 @default.
- W2079134736 cites W2100290637 @default.
- W2079134736 cites W2101606792 @default.
- W2079134736 cites W2106851652 @default.
- W2079134736 cites W2110095667 @default.
- W2079134736 cites W2111041043 @default.
- W2079134736 cites W2114091391 @default.
- W2079134736 cites W2116365403 @default.
- W2079134736 cites W2121004390 @default.
- W2079134736 cites W2123355863 @default.
- W2079134736 cites W2123556420 @default.
- W2079134736 cites W2133487216 @default.
- W2079134736 cites W2136019899 @default.
- W2079134736 cites W2142716454 @default.
- W2079134736 cites W2144966005 @default.
- W2079134736 cites W2146972564 @default.
- W2079134736 cites W2150929583 @default.
- W2079134736 cites W2152125466 @default.
- W2079134736 cites W2155652302 @default.
- W2079134736 cites W2158698668 @default.
- W2079134736 cites W2316145923 @default.
- W2079134736 doi "https://doi.org/10.1007/s12264-013-1311-5" @default.
- W2079134736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5561874" @default.
- W2079134736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23456565" @default.
- W2079134736 hasPublicationYear "2013" @default.
- W2079134736 type Work @default.
- W2079134736 sameAs 2079134736 @default.
- W2079134736 citedByCount "38" @default.
- W2079134736 countsByYear W20791347362013 @default.
- W2079134736 countsByYear W20791347362014 @default.
- W2079134736 countsByYear W20791347362015 @default.
- W2079134736 countsByYear W20791347362016 @default.
- W2079134736 countsByYear W20791347362017 @default.
- W2079134736 countsByYear W20791347362018 @default.
- W2079134736 countsByYear W20791347362019 @default.
- W2079134736 countsByYear W20791347362020 @default.
- W2079134736 countsByYear W20791347362021 @default.
- W2079134736 countsByYear W20791347362022 @default.
- W2079134736 countsByYear W20791347362023 @default.
- W2079134736 crossrefType "journal-article" @default.
- W2079134736 hasAuthorship W2079134736A5001959448 @default.
- W2079134736 hasAuthorship W2079134736A5032012066 @default.
- W2079134736 hasAuthorship W2079134736A5050051706 @default.
- W2079134736 hasAuthorship W2079134736A5068093752 @default.
- W2079134736 hasBestOaLocation W20791347362 @default.
- W2079134736 hasConcept C126838900 @default.
- W2079134736 hasConcept C142724271 @default.
- W2079134736 hasConcept C143409427 @default.
- W2079134736 hasConcept C169760540 @default.
- W2079134736 hasConcept C2776985911 @default.
- W2079134736 hasConcept C2778376644 @default.
- W2079134736 hasConcept C2778609137 @default.
- W2079134736 hasConcept C2779234561 @default.
- W2079134736 hasConcept C2779530196 @default.
- W2079134736 hasConcept C2779965356 @default.
- W2079134736 hasConcept C2780123866 @default.
- W2079134736 hasConcept C2781192897 @default.
- W2079134736 hasConcept C2781458332 @default.
- W2079134736 hasConcept C529278444 @default.