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- W2079138188 abstract "The humoral immune response after primary and re-vaccination confirmed the high immunogenicity of the combined vaccines used: MMR-Vax(R), Pluserix(R) and Triviraten(R). The investigation of paired serum samples of prevaccinal seronegative infants (n90-100% for all three components with the exception of the mumps component of Triviraten(R) (38%). However, by additional methods (plaque neutralisation test, immunofluorescence test) mumps antibodies could be detected in 93.4% of infants having received vaccine Triviraten(R). The mean values of antibody activities against the three components did not differ significantly after vaccination with MMR-Vax(R) and Pluserix(R). However, after vaccination with Triviraten(R) the mean antibody values were significantly lower (P<0.01) against the measles strain Edmonston-Zagreb and especially lower (2-20 times) against the mumps virus strain Rubini. Revaccination of pre-vaccinal seropositive schoolchildren and adolescents (n=676) with MMR-Vax(R) and Pluserix(R) produced no different results. The rate of vaccinees responding with a booster reaction reached 68.4% for measles and mumps, but only 8.6% for rubella. A booster reaction could be observed in 100% of those vaccinees who had antibodies at a low level, also in the case of naturally acquired immunity. The low-level range for antibodies against measles was defined as 0.15<0. 40 IU/ml, mumps 1:230</=1:500 and rubella 7-16 IU/ml. The rate of vaccinees with low-level antibodies against measles can become as high as 10%, for mumps 20% and for rubella 3%. The correlation between the level of antibodies and protection against the disease is discussed. The rate of individuals in a population with doubtful protection (unvaccinated, non-responder and low responder after primary vaccination) prevents to reach the herd immunity of 95% necessary for elimination. The results of our serological studies strongly recommend re-vaccination against measles, mumps and rubella." @default.
- W2079138188 created "2016-06-24" @default.
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- W2079138188 date "2000-02-01" @default.
- W2079138188 modified "2023-09-27" @default.
- W2079138188 title "Immune response after primary and re-vaccination with different combined vaccines against measles, mumps, rubella" @default.
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- W2079138188 doi "https://doi.org/10.1016/s0264-410x(99)00397-7" @default.
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