FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079140131> ?p ?o ?g. }

• W2079140131 endingPage "337" @default.
• W2079140131 startingPage "332" @default.
• W2079140131 abstract "Desferrioxamine, an iron chelator with hypoxia-mimetic activity, promotes bone mineralization when used in aluminum-overloaded dialysis patients. However, the effect of desferrioxamine on osteoblastic differentiation from pluripotent mesenchymal stem cells (MSCs) has not been reported. In this study, pluripotent human MSCs and murine mesenchymal C3H10T1/2 cells were simultaneously treated with desferrioxamine and bone morphogenetic protein-2 (BMP2). In BMP2-treated MSCs, desferrioxamine levels of 15 microMu were found to increase alkaline phosphatase (ALP) activity and calcium deposition, which were the markers of osteoblastic differentiation. These effects of desferrioxamine were accompanied by promoted phosphorylation of glycogen synthase kinase 3beta (GSK-3beta) and increased beta-catenin protein content, a direct GSK-3beta substrate. Knockdown of beta-catenin by RNA interference eliminates this positive effect of desferrioxamine on ALP activity. Taken together, these data demonstrate that desferrioxamine plays a direct role in the differentiation of mesenchymal stem cells by activating beta-catenin signaling cascades." @default.
• W2079140131 created "2016-06-24" @default.
• W2079140131 creator A5053367167 @default.
• W2079140131 creator A5062413297 @default.
• W2079140131 creator A5073742261 @default.
• W2079140131 creator A5083632480 @default.
• W2079140131 date "2008-05-01" @default.
• W2079140131 modified "2023-10-15" @default.
• W2079140131 title "Promotion of osteogenesis through β-catenin signaling by desferrioxamine" @default.
• W2079140131 cites W1967951907 @default.
• W2079140131 cites W1971077979 @default.
• W2079140131 cites W1980087281 @default.
• W2079140131 cites W1981919068 @default.
• W2079140131 cites W1989215255 @default.
• W2079140131 cites W1990246447 @default.
• W2079140131 cites W1994842522 @default.
• W2079140131 cites W1996086031 @default.
• W2079140131 cites W2000167893 @default.
• W2079140131 cites W2002043863 @default.
• W2079140131 cites W2007566603 @default.
• W2079140131 cites W2017620128 @default.
• W2079140131 cites W2029187758 @default.
• W2079140131 cites W2034887444 @default.
• W2079140131 cites W2043162569 @default.
• W2079140131 cites W2052127095 @default.
• W2079140131 cites W2104100666 @default.
• W2079140131 cites W2110186943 @default.
• W2079140131 cites W2149433248 @default.
• W2079140131 cites W2169533924 @default.
• W2079140131 doi "https://doi.org/10.1016/j.bbrc.2008.03.092" @default.
• W2079140131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18375202" @default.
• W2079140131 hasPublicationYear "2008" @default.
• W2079140131 type Work @default.
• W2079140131 sameAs 2079140131 @default.
• W2079140131 citedByCount "53" @default.
• W2079140131 countsByYear W20791401312012 @default.
• W2079140131 countsByYear W20791401312013 @default.
• W2079140131 countsByYear W20791401312014 @default.
• W2079140131 countsByYear W20791401312015 @default.
• W2079140131 countsByYear W20791401312016 @default.
• W2079140131 countsByYear W20791401312017 @default.
• W2079140131 countsByYear W20791401312018 @default.
• W2079140131 countsByYear W20791401312020 @default.
• W2079140131 countsByYear W20791401312021 @default.
• W2079140131 countsByYear W20791401312022 @default.
• W2079140131 countsByYear W20791401312023 @default.
• W2079140131 crossrefType "journal-article" @default.
• W2079140131 hasAuthorship W2079140131A5053367167 @default.
• W2079140131 hasAuthorship W2079140131A5062413297 @default.
• W2079140131 hasAuthorship W2079140131A5073742261 @default.
• W2079140131 hasAuthorship W2079140131A5083632480 @default.
• W2079140131 hasConcept C104317684 @default.
• W2079140131 hasConcept C11960822 @default.
• W2079140131 hasConcept C125349252 @default.
• W2079140131 hasConcept C160160445 @default.
• W2079140131 hasConcept C181199279 @default.
• W2079140131 hasConcept C181628713 @default.
• W2079140131 hasConcept C185592680 @default.
• W2079140131 hasConcept C198826908 @default.
• W2079140131 hasConcept C202751555 @default.
• W2079140131 hasConcept C2776672577 @default.
• W2079140131 hasConcept C30352789 @default.
• W2079140131 hasConcept C31507581 @default.
• W2079140131 hasConcept C502942594 @default.
• W2079140131 hasConcept C55493867 @default.
• W2079140131 hasConcept C86803240 @default.
• W2079140131 hasConcept C95444343 @default.
• W2079140131 hasConceptScore W2079140131C104317684 @default.
• W2079140131 hasConceptScore W2079140131C11960822 @default.
• W2079140131 hasConceptScore W2079140131C125349252 @default.
• W2079140131 hasConceptScore W2079140131C160160445 @default.
• W2079140131 hasConceptScore W2079140131C181199279 @default.
• W2079140131 hasConceptScore W2079140131C181628713 @default.
• W2079140131 hasConceptScore W2079140131C185592680 @default.
• W2079140131 hasConceptScore W2079140131C198826908 @default.
• W2079140131 hasConceptScore W2079140131C202751555 @default.
• W2079140131 hasConceptScore W2079140131C2776672577 @default.
• W2079140131 hasConceptScore W2079140131C30352789 @default.
• W2079140131 hasConceptScore W2079140131C31507581 @default.
• W2079140131 hasConceptScore W2079140131C502942594 @default.
• W2079140131 hasConceptScore W2079140131C55493867 @default.
• W2079140131 hasConceptScore W2079140131C86803240 @default.
• W2079140131 hasConceptScore W2079140131C95444343 @default.
• W2079140131 hasIssue "2" @default.
• W2079140131 hasLocation W20791401311 @default.
• W2079140131 hasLocation W20791401312 @default.
• W2079140131 hasOpenAccess W2079140131 @default.
• W2079140131 hasPrimaryLocation W20791401311 @default.
• W2079140131 hasRelatedWork W1966334367 @default.
• W2079140131 hasRelatedWork W2341287719 @default.
• W2079140131 hasRelatedWork W2377565672 @default.
• W2079140131 hasRelatedWork W2606517225 @default.
• W2079140131 hasRelatedWork W2810322885 @default.
• W2079140131 hasRelatedWork W2919616119 @default.
• W2079140131 hasRelatedWork W3046968286 @default.
• W2079140131 hasRelatedWork W4230801422 @default.
• W2079140131 hasRelatedWork W4242486335 @default.
• W2079140131 hasRelatedWork W772279174 @default.

• next