FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079140686> ?p ?o ?g. }

• W2079140686 endingPage "1113" @default.
• W2079140686 startingPage "1105" @default.
• W2079140686 abstract "Bombesin-related peptides are growth factors for a variety of cells, including normal human bronchial epithelial cells. An ELISA for bombesin-like peptides (BLP) has been devised using the MAb BBC353, which is specific for the biologically active carboxy-terminal fragment shared by all known BLP. Using this ELISA, we measured bronchoalveolar lavage (BAL) fluid levels of BLP in normal cigarette smokers (n = 15) and normal nonsmokers (n = 18). Smokers' BAL fluid contained increased levels of BLP, whether expressed in terms of BAL fluid volume (P = 0.0001) or protein content (P less than 0.05). BLP levels did not correlate with any cellular constituent in the BAL fluid but immunostaining of lung tissue with BBC353 revealed an intense specific staining of neuroendocrine cells, implying these as a potential source. Two peaks of bombesin-like immunoreactivity were purified using sequential reverse phase and gel filtration HPLC. Both BLP have apparent molecular weights similar to gastrin-releasing peptide on gel filtration HPLC analysis. However, the amino acid composition of these BLP is different from that of gastrin-releasing peptide or neuromedin B, the only known mammalian forms of BLP, suggesting either incomplete purification or novel peptides. Sequence analysis could not be performed due to blocking groups at the amino terminus of these peptides. Our data demonstrate that cigarette smoking is associated with increased levels of pulmonary BLP and imply a potential role for these neuropeptides in the lung's response to tobacco smoke." @default.
• W2079140686 created "2016-06-24" @default.
• W2079140686 creator A5002273999 @default.
• W2079140686 creator A5008812839 @default.
• W2079140686 creator A5030267407 @default.
• W2079140686 creator A5048795122 @default.
• W2079140686 creator A5062057801 @default.
• W2079140686 creator A5073222544 @default.
• W2079140686 date "1989-10-01" @default.
• W2079140686 modified "2023-10-16" @default.
• W2079140686 title "Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic cigarette smokers." @default.
• W2079140686 cites W1513897573 @default.
• W2079140686 cites W1528679529 @default.
• W2079140686 cites W1974094437 @default.
• W2079140686 cites W1977644590 @default.
• W2079140686 cites W1982186695 @default.
• W2079140686 cites W1982613869 @default.
• W2079140686 cites W2019042050 @default.
• W2079140686 cites W2030167821 @default.
• W2079140686 cites W2030522563 @default.
• W2079140686 cites W2030954798 @default.
• W2079140686 cites W2031423487 @default.
• W2079140686 cites W2031956553 @default.
• W2079140686 cites W2054585524 @default.
• W2079140686 cites W2056194238 @default.
• W2079140686 cites W2065328037 @default.
• W2079140686 cites W2075260565 @default.
• W2079140686 cites W2081394510 @default.
• W2079140686 cites W2081771816 @default.
• W2079140686 cites W2094847800 @default.
• W2079140686 cites W2139258764 @default.
• W2079140686 cites W2312914098 @default.
• W2079140686 cites W2411130954 @default.
• W2079140686 cites W2413064345 @default.
• W2079140686 cites W2419191568 @default.
• W2079140686 cites W375444644 @default.
• W2079140686 doi "https://doi.org/10.1172/jci114273" @default.
• W2079140686 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/329766" @default.
• W2079140686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2794048" @default.
• W2079140686 hasPublicationYear "1989" @default.
• W2079140686 type Work @default.
• W2079140686 sameAs 2079140686 @default.
• W2079140686 citedByCount "119" @default.
• W2079140686 countsByYear W20791406862013 @default.
• W2079140686 countsByYear W20791406862014 @default.
• W2079140686 countsByYear W20791406862016 @default.
• W2079140686 countsByYear W20791406862017 @default.
• W2079140686 countsByYear W20791406862018 @default.
• W2079140686 countsByYear W20791406862019 @default.
• W2079140686 countsByYear W20791406862020 @default.
• W2079140686 countsByYear W20791406862021 @default.
• W2079140686 countsByYear W20791406862023 @default.
• W2079140686 crossrefType "journal-article" @default.
• W2079140686 hasAuthorship W2079140686A5002273999 @default.
• W2079140686 hasAuthorship W2079140686A5008812839 @default.
• W2079140686 hasAuthorship W2079140686A5030267407 @default.
• W2079140686 hasAuthorship W2079140686A5048795122 @default.
• W2079140686 hasAuthorship W2079140686A5062057801 @default.
• W2079140686 hasAuthorship W2079140686A5073222544 @default.
• W2079140686 hasBestOaLocation W20791406861 @default.
• W2079140686 hasConcept C118303440 @default.
• W2079140686 hasConcept C126322002 @default.
• W2079140686 hasConcept C134018914 @default.
• W2079140686 hasConcept C153911025 @default.
• W2079140686 hasConcept C170493617 @default.
• W2079140686 hasConcept C185592680 @default.
• W2079140686 hasConcept C204232928 @default.
• W2079140686 hasConcept C2776998989 @default.
• W2079140686 hasConcept C2777714996 @default.
• W2079140686 hasConcept C2777961210 @default.
• W2079140686 hasConcept C2778448772 @default.
• W2079140686 hasConcept C2779281246 @default.
• W2079140686 hasConcept C4224716 @default.
• W2079140686 hasConcept C55493867 @default.
• W2079140686 hasConcept C71924100 @default.
• W2079140686 hasConcept C86803240 @default.
• W2079140686 hasConceptScore W2079140686C118303440 @default.
• W2079140686 hasConceptScore W2079140686C126322002 @default.
• W2079140686 hasConceptScore W2079140686C134018914 @default.
• W2079140686 hasConceptScore W2079140686C153911025 @default.
• W2079140686 hasConceptScore W2079140686C170493617 @default.
• W2079140686 hasConceptScore W2079140686C185592680 @default.
• W2079140686 hasConceptScore W2079140686C204232928 @default.
• W2079140686 hasConceptScore W2079140686C2776998989 @default.
• W2079140686 hasConceptScore W2079140686C2777714996 @default.
• W2079140686 hasConceptScore W2079140686C2777961210 @default.
• W2079140686 hasConceptScore W2079140686C2778448772 @default.
• W2079140686 hasConceptScore W2079140686C2779281246 @default.
• W2079140686 hasConceptScore W2079140686C4224716 @default.
• W2079140686 hasConceptScore W2079140686C55493867 @default.
• W2079140686 hasConceptScore W2079140686C71924100 @default.
• W2079140686 hasConceptScore W2079140686C86803240 @default.
• W2079140686 hasIssue "4" @default.
• W2079140686 hasLocation W20791406861 @default.
• W2079140686 hasLocation W20791406862 @default.
• W2079140686 hasLocation W20791406863 @default.
• W2079140686 hasLocation W20791406864 @default.
• W2079140686 hasLocation W20791406865 @default.

• next