FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079143155> ?p ?o ?g. }

• W2079143155 endingPage "269" @default.
• W2079143155 startingPage "259" @default.
• W2079143155 abstract "Multiple gene transfer might permit modulation of concurrent biochemical pathways involved in lung graft ischemia-reperfusion injury. In this study we analyzed whether recipient intramuscular naked plasmid cotransfection of transforming growth factor beta(1) and interleukin 10 would result in amelioration of lung graft ischemia-reperfusion injury.Forty-eight hours before transplantation, 6 groups (n = 6) of F344 rats received intramuscular injection of naked plasmid encoding chloramphenicol acetyltransferase, chloramphenicol acetyltransferase plus beta-galactosidase, transforming growth factor beta(1), interleukin 10, or transforming growth factor beta(1) plus interleukin 10 or were not treated. Donor lungs were flushed and stored for 18 hours at 4 degrees C before transplantation. Twenty-four hours later, grafts were assessed immediately before the animals were killed. Arterial oxygenation, wet/dry ratio, myeloperoxidase, and proinflammatory cytokines (interleukin 1, tumor necrosis factor alpha, interferon gamma, and interleukin 2) were measured, and immunohistochemistry was performed.For lung graft function, the arterial oxygenation was considerably higher in the cotransfected group receiving transforming growth factor beta(1) plus interleukin 10 compared with that in all other groups (P < or =.03). The wet/dry ratio, reflecting lung edema, was reduced in the cotransfected group compared with that in control animals (nontreated, P <.02; chloramphenicol acetyltransferase, P <.03; chloramphenicol acetyltransferase plus beta-galactosidase, P <.01). Myeloperoxidase, which measures neutrophil sequestration, was also reduced with cotransfection compared with that seen in control animals (P < or =.03). All proinflammatory cytokines were decreased in the cotransfected group compared with those in all other groups (interleukin 1beta, P <.04; tumor necrosis factor alpha, P <.002; interferon gamma, P <.0001; interleukin 2, P <.03). These results indicate that cotransfection provides a synergistic benefit in graft function versus either cytokine alone, neutrophil sequestration, or inflammatory cytokine expression. Immunohistochemistry showed positive staining of transforming growth factor beta(1) plus interleukin 10 in type I and II pneumocytes and localized edema fluid.Recipient intramuscular naked plasmid cotransfection of transforming growth factor beta(1) and interleukin 10 provides a synergistic effect in ameliorating lung reperfusion injury after prolonged ischemia." @default.
• W2079143155 created "2016-06-24" @default.
• W2079143155 creator A5000381347 @default.
• W2079143155 creator A5001045635 @default.
• W2079143155 creator A5003532601 @default.
• W2079143155 creator A5021338777 @default.
• W2079143155 creator A5034151452 @default.
• W2079143155 creator A5041655105 @default.
• W2079143155 creator A5048361872 @default.
• W2079143155 creator A5064875263 @default.
• W2079143155 creator A5069915539 @default.
• W2079143155 creator A5070432469 @default.
• W2079143155 creator A5078474269 @default.
• W2079143155 date "2002-08-01" @default.
• W2079143155 modified "2023-10-11" @default.
• W2079143155 title "Recipient intramuscular cotransfection of naked plasmid transforming growth factor β1 and interleukin 10 ameliorates lung graft ischemia-reperfusion injury" @default.
• W2079143155 cites W1557181127 @default.
• W2079143155 cites W1562463009 @default.
• W2079143155 cites W1969785946 @default.
• W2079143155 cites W1972456273 @default.
• W2079143155 cites W1998966945 @default.
• W2079143155 cites W2010861038 @default.
• W2079143155 cites W2013058158 @default.
• W2079143155 cites W2014495927 @default.
• W2079143155 cites W2022434236 @default.
• W2079143155 cites W2023144855 @default.
• W2079143155 cites W2030694116 @default.
• W2079143155 cites W2032678451 @default.
• W2079143155 cites W2042745519 @default.
• W2079143155 cites W2051729665 @default.
• W2079143155 cites W2058560613 @default.
• W2079143155 cites W2080085786 @default.
• W2079143155 cites W2086728925 @default.
• W2079143155 cites W2098221319 @default.
• W2079143155 cites W2101771134 @default.
• W2079143155 cites W2108080729 @default.
• W2079143155 cites W2129379081 @default.
• W2079143155 cites W2136392861 @default.
• W2079143155 cites W2146898483 @default.
• W2079143155 cites W2156953890 @default.
• W2079143155 cites W2316067769 @default.
• W2079143155 cites W2414792168 @default.
• W2079143155 cites W267694688 @default.
• W2079143155 cites W4229829133 @default.
• W2079143155 cites W4231581694 @default.
• W2079143155 cites W4301882029 @default.
• W2079143155 cites W4323241890 @default.
• W2079143155 doi "https://doi.org/10.1067/mtc.2002.122295" @default.
• W2079143155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12167785" @default.
• W2079143155 hasPublicationYear "2002" @default.
• W2079143155 type Work @default.
• W2079143155 sameAs 2079143155 @default.
• W2079143155 citedByCount "16" @default.
• W2079143155 countsByYear W20791431552013 @default.
• W2079143155 countsByYear W20791431552016 @default.
• W2079143155 countsByYear W20791431552022 @default.
• W2079143155 crossrefType "journal-article" @default.
• W2079143155 hasAuthorship W2079143155A5000381347 @default.
• W2079143155 hasAuthorship W2079143155A5001045635 @default.
• W2079143155 hasAuthorship W2079143155A5003532601 @default.
• W2079143155 hasAuthorship W2079143155A5021338777 @default.
• W2079143155 hasAuthorship W2079143155A5034151452 @default.
• W2079143155 hasAuthorship W2079143155A5041655105 @default.
• W2079143155 hasAuthorship W2079143155A5048361872 @default.
• W2079143155 hasAuthorship W2079143155A5064875263 @default.
• W2079143155 hasAuthorship W2079143155A5069915539 @default.
• W2079143155 hasAuthorship W2079143155A5070432469 @default.
• W2079143155 hasAuthorship W2079143155A5078474269 @default.
• W2079143155 hasBestOaLocation W20791431551 @default.
• W2079143155 hasConcept C126322002 @default.
• W2079143155 hasConcept C134018914 @default.
• W2079143155 hasConcept C164027704 @default.
• W2079143155 hasConcept C203014093 @default.
• W2079143155 hasConcept C203565725 @default.
• W2079143155 hasConcept C2776914184 @default.
• W2079143155 hasConcept C2778690821 @default.
• W2079143155 hasConcept C2780114680 @default.
• W2079143155 hasConcept C541997718 @default.
• W2079143155 hasConcept C71924100 @default.
• W2079143155 hasConcept C74172505 @default.
• W2079143155 hasConceptScore W2079143155C126322002 @default.
• W2079143155 hasConceptScore W2079143155C134018914 @default.
• W2079143155 hasConceptScore W2079143155C164027704 @default.
• W2079143155 hasConceptScore W2079143155C203014093 @default.
• W2079143155 hasConceptScore W2079143155C203565725 @default.
• W2079143155 hasConceptScore W2079143155C2776914184 @default.
• W2079143155 hasConceptScore W2079143155C2778690821 @default.
• W2079143155 hasConceptScore W2079143155C2780114680 @default.
• W2079143155 hasConceptScore W2079143155C541997718 @default.
• W2079143155 hasConceptScore W2079143155C71924100 @default.
• W2079143155 hasConceptScore W2079143155C74172505 @default.
• W2079143155 hasIssue "2" @default.
• W2079143155 hasLocation W20791431551 @default.
• W2079143155 hasLocation W20791431552 @default.
• W2079143155 hasOpenAccess W2079143155 @default.
• W2079143155 hasPrimaryLocation W20791431551 @default.
• W2079143155 hasRelatedWork W2003273883 @default.
• W2079143155 hasRelatedWork W2010980463 @default.

• next