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- W2079143417 abstract "1 To investigate the effect of hypothalamic application of histamine agonists and antagonists on the pressor response to hypothalamic stimulation, the posterior hypothalamus of anaesthetized cats was superfused with drugs through a push-pull cannula and electrically stimulated with the non-insulated tip of the cannula. 2 Superfusion of the posterior hypothalamic area with histamine enhanced the pressor response to hypothalamic stimulation. The most pronounced effect of histamine was found, when the caudal region of the posterior hypothalamic area was superfused. The enhancing effect of histamine was abolished when the hypothalamus was pre-superfused with metiamide; it was slightly inhibited by pre-superfusion with mepyramine. 3 Dimaprit also enhanced the pressor response to hypothalamic stimulation; the effect of this drug was abolished by metiamide, whilst hypothalamic pre-superfusion with mepyramine was ineffective. 4 Superfusion of the hypothalamus with 2-methylhistamine did not change the pressor response to hypothalamic stimulation. 5 The enhancing effect of histamine was abolished by hypothalamic pre-superfusion with phentolamine, phenoxybenzamine or propranolol. 6 It is concluded that histamine enhances the pressor response to hypothalamic stimulation mainly by acting on H2-receptors of the posterior hypothalamus. The inhibition of the effect of histamine by α-and β-adrenoreceptor blocking agents indicates the involvement of catecholaminergic systems of the hypothalamus." @default.
- W2079143417 created "2016-06-24" @default.
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- W2079143417 date "1981-03-01" @default.
- W2079143417 modified "2023-09-28" @default.
- W2079143417 title "HYPOTHALAMIC SUPERFUSION WITH HISTAMINE AGONISTS AND ANTAGONISTS MODIFIES THE PRESSOR RESPONSE TO HYPOTHALAMIC STIMULATION" @default.
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- W2079143417 doi "https://doi.org/10.1111/j.1474-8673.1981.tb00502.x" @default.
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