FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079144150> ?p ?o ?g. }

• W2079144150 abstract "You have accessJournal of UrologyKidney Cancer: Basic Research II1 Apr 2010218 DOWN-REGULATION OF MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE-1 EXPRESSION PREDICTS FOR POOR SURVIVAL IN RENAL CELL CARCINOMA Ryuichi Mizuno, Kenjiro Ishibashi, Hidaka Kono, Eiji Kikuchi, Hirohiko Nagata, Hiroshi Asanuma, Akira Miyajima, Ken Nakagawa, and Mototsugu Oya Ryuichi MizunoRyuichi Mizuno More articles by this author , Kenjiro IshibashiKenjiro Ishibashi More articles by this author , Hidaka KonoHidaka Kono More articles by this author , Eiji KikuchiEiji Kikuchi More articles by this author , Hirohiko NagataHirohiko Nagata More articles by this author , Hiroshi AsanumaHiroshi Asanuma More articles by this author , Akira MiyajimaAkira Miyajima More articles by this author , Ken NakagawaKen Nakagawa More articles by this author , and Mototsugu OyaMototsugu Oya More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.275AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Mitogen-activated protein kinases (MAPKs) have been known to play a critical role in both the proliferative and apoptotic signal transduction pathways.This study was designed to investigate the possible significance of Mitogen-activated protein kinase phosphatase-1 (MKP-1) in renal cell carcinomas (RCCs). METHODS The MKP-1 expression was analyzed by quantitative PCR, Western blotting and immunostainig in 51 cases of human RCCs and 2 renal cancer cell lines, i.e. A498, and 786O. The effects of human recombinant EGF (hrEGF) on the expression of MKP-1 on renal cancer cell lines were analyzed by Western blotting. Chi-square tests were performed to test the relationships between MKP-1 expression status and clinicopathological parameters. MKP-1 expression and clinicopathological variables were evaluated for association with overall survival using Kaplan-Meier survival analysis with log-rank statistic for determining significance. RESULTS When the cells were treated with hrEGF, the MKP-1 expression was up-regulated with the activation of extracellular signal-regulated protein kinase (ERK) in both cell lines. MKP-1 immunostaining was widely distributed both in tumor and matched normal kidney tissues. In normal kidney, MKP-1 expression was detected in the renal tubular epithelium. Generally, immunostaining was found in the nucleus and in the cytoplasm. RCC tumor specimens exhibited marked variability in their levels of MKP-1. Generally, immunostaining was found both in the nucleus and on the cell membrane. MKP-1 expression was up-regulated in RCCs compared with normal kidney tissue. Association between MKP-1 expression and clinicopathological variables were evaluated using chi-square test. Low MKP-1 expression was correlated with high tumor grade (p=0.0093). Survival analyses showed that low MKP-1 protein expression (p=0.0006) high tumor grade (p=0.0007), and high T stage (p<0.0001) are associated with poor overall survival. CONCLUSIONS Our cell line study results suggest the mitogenic signal, which result in ERK activation, seemed to be associated with MKP-1 up-regulation. Our data also indicated that MKP-1 expression is generally up-regulated in RCCs but is down-regulated in high grade cancer. Since low MKP-1 expression in RCCs was associated with poor overall survival, MKP-1 seems to have the potential as a prognostic marker in RCCs. Tokyo, Japan© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e85-e86 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ryuichi Mizuno More articles by this author Kenjiro Ishibashi More articles by this author Hidaka Kono More articles by this author Eiji Kikuchi More articles by this author Hirohiko Nagata More articles by this author Hiroshi Asanuma More articles by this author Akira Miyajima More articles by this author Ken Nakagawa More articles by this author Mototsugu Oya More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W2079144150 created "2016-06-24" @default.
• W2079144150 creator A5008830530 @default.
• W2079144150 creator A5017099114 @default.
• W2079144150 creator A5017359886 @default.
• W2079144150 creator A5024744698 @default.
• W2079144150 creator A5032752800 @default.
• W2079144150 creator A5053961273 @default.
• W2079144150 creator A5069423724 @default.
• W2079144150 creator A5071103147 @default.
• W2079144150 creator A5086644570 @default.
• W2079144150 date "2010-04-01" @default.
• W2079144150 modified "2023-09-23" @default.
• W2079144150 title "218 DOWN-REGULATION OF MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE-1 EXPRESSION PREDICTS FOR POOR SURVIVAL IN RENAL CELL CARCINOMA" @default.
• W2079144150 doi "https://doi.org/10.1016/j.juro.2010.02.275" @default.
• W2079144150 hasPublicationYear "2010" @default.
• W2079144150 type Work @default.
• W2079144150 sameAs 2079144150 @default.
• W2079144150 citedByCount "0" @default.
• W2079144150 crossrefType "journal-article" @default.
• W2079144150 hasAuthorship W2079144150A5008830530 @default.
• W2079144150 hasAuthorship W2079144150A5017099114 @default.
• W2079144150 hasAuthorship W2079144150A5017359886 @default.
• W2079144150 hasAuthorship W2079144150A5024744698 @default.
• W2079144150 hasAuthorship W2079144150A5032752800 @default.
• W2079144150 hasAuthorship W2079144150A5053961273 @default.
• W2079144150 hasAuthorship W2079144150A5069423724 @default.
• W2079144150 hasAuthorship W2079144150A5071103147 @default.
• W2079144150 hasAuthorship W2079144150A5086644570 @default.
• W2079144150 hasConcept C104317684 @default.
• W2079144150 hasConcept C11960822 @default.
• W2079144150 hasConcept C121608353 @default.
• W2079144150 hasConcept C126322002 @default.
• W2079144150 hasConcept C132149769 @default.
• W2079144150 hasConcept C178666793 @default.
• W2079144150 hasConcept C184235292 @default.
• W2079144150 hasConcept C2777472916 @default.
• W2079144150 hasConcept C502942594 @default.
• W2079144150 hasConcept C55493867 @default.
• W2079144150 hasConcept C62478195 @default.
• W2079144150 hasConcept C71924100 @default.
• W2079144150 hasConcept C85265743 @default.
• W2079144150 hasConcept C86803240 @default.
• W2079144150 hasConcept C95444343 @default.
• W2079144150 hasConcept C97029542 @default.
• W2079144150 hasConceptScore W2079144150C104317684 @default.
• W2079144150 hasConceptScore W2079144150C11960822 @default.
• W2079144150 hasConceptScore W2079144150C121608353 @default.
• W2079144150 hasConceptScore W2079144150C126322002 @default.
• W2079144150 hasConceptScore W2079144150C132149769 @default.
• W2079144150 hasConceptScore W2079144150C178666793 @default.
• W2079144150 hasConceptScore W2079144150C184235292 @default.
• W2079144150 hasConceptScore W2079144150C2777472916 @default.
• W2079144150 hasConceptScore W2079144150C502942594 @default.
• W2079144150 hasConceptScore W2079144150C55493867 @default.
• W2079144150 hasConceptScore W2079144150C62478195 @default.
• W2079144150 hasConceptScore W2079144150C71924100 @default.
• W2079144150 hasConceptScore W2079144150C85265743 @default.
• W2079144150 hasConceptScore W2079144150C86803240 @default.
• W2079144150 hasConceptScore W2079144150C95444343 @default.
• W2079144150 hasConceptScore W2079144150C97029542 @default.
• W2079144150 hasIssue "4S" @default.
• W2079144150 hasLocation W20791441501 @default.
• W2079144150 hasOpenAccess W2079144150 @default.
• W2079144150 hasPrimaryLocation W20791441501 @default.
• W2079144150 hasRelatedWork W1581150137 @default.
• W2079144150 hasRelatedWork W1976734851 @default.
• W2079144150 hasRelatedWork W1985530681 @default.
• W2079144150 hasRelatedWork W2008538530 @default.
• W2079144150 hasRelatedWork W2350517500 @default.
• W2079144150 hasRelatedWork W2354036423 @default.
• W2079144150 hasRelatedWork W2904629657 @default.
• W2079144150 hasRelatedWork W3141260101 @default.
• W2079144150 hasRelatedWork W4254421120 @default.
• W2079144150 hasRelatedWork W83034047 @default.
• W2079144150 hasVolume "183" @default.
• W2079144150 isParatext "false" @default.
• W2079144150 isRetracted "false" @default.
• W2079144150 magId "2079144150" @default.
• W2079144150 workType "article" @default.