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- W2079144484 abstract "NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development. Keywords: Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design" @default.
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- W2079144484 date "2006-07-01" @default.
- W2079144484 modified "2023-10-03" @default.
- W2079144484 title "Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies" @default.
- W2079144484 doi "https://doi.org/10.2174/138955706777698651" @default.
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