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- W2079148004 startingPage "183" @default.
- W2079148004 abstract "Hepatic encephalopathy (HE)1 is a common neuropsychiatric complication of both acute and chronic liver disease. Clinical symptoms may include motor disturbances and cognitive dysfunction. Available animal models of HE mimic the deficits in cognitive performance including the impaired ability to learn and memorize information. This review explores the question how HE might affect cognitive functions at molecular levels. Both acute and chronic models of HE constrain the plasticity of glutamatergic neurotransmission. Thus, long-lasting activity-dependent changes in synaptic efficiency, known as long-term potentiation (LTP) and long-term depression (LTD) are significantly impeded. We discuss molecules and signal transduction pathways of LTP and LTD that are targeted by experimental HE, with a focus on ionotropic glutamate receptors of the AMPA-subtype. Finally, a novel strategy of functional proteomic analysis is presented, which, if applied differentially, may provide molecular insight into disease-related dysfunction of membrane protein complexes, i.e. disturbed ionotropic glutamate receptor signaling in HE." @default.
- W2079148004 created "2016-06-24" @default.
- W2079148004 creator A5038091996 @default.
- W2079148004 creator A5055675007 @default.
- W2079148004 creator A5082575890 @default.
- W2079148004 date "2013-08-01" @default.
- W2079148004 modified "2023-10-16" @default.
- W2079148004 title "Synaptic plasticity in hepatic encephalopathy – A molecular perspective" @default.
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