FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079149074> ?p ?o ?g. }

• W2079149074 endingPage "13207" @default.
• W2079149074 startingPage "13203" @default.
• W2079149074 abstract "Cognitive impairment has recently been found to correlate with changes in peripheral inflammatory signals such as TNF-α and IL-1β. PKC isozymes regulate levels of TNF-α and IL-6 and the release of other cytokines and also show deficits in Alzheimer’s disease (AD) brains and skin fibroblasts. Here, we investigate MAPK Erk1 and Erk2 phosphorylation in response to the inflammatory agonist bradykinin, which activates PKC pathways. An internally controlled comparison of Erk1 and Erk2 produced an AD index that accurately distinguished fibroblasts of AD from those of normal controls and of non-AD dementias. This accuracy was demonstrated for Coriell Cell Repository (Coriell Institute of Medical Research, Camden, NJ) samples, as well as for samples analyzed on gels with autopsy diagnostic confirmation. AD Erk1 and Erk2 index values were inversely correlated with disease duration, suggesting maximal efficacy for early diagnosis. Finally, the results also demonstrate that, when the AD index agreed with the clinical diagnosis on the presence of AD, there was a high probability of accuracy based on autopsy validation. Thus, this peripheral molecular biomarker, based on differential Erk1 and Erk2 phosphorylation, could have important clinical utility for providing increased certainty in the positive diagnosis of AD, particularly in the early phase of disease progression." @default.
• W2079149074 created "2016-06-24" @default.
• W2079149074 creator A5069384522 @default.
• W2079149074 creator A5072355639 @default.
• W2079149074 date "2006-08-29" @default.
• W2079149074 modified "2023-10-01" @default.
• W2079149074 title "An internally controlled peripheral biomarker for Alzheimer’s disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin" @default.
• W2079149074 cites W1829764364 @default.
• W2079149074 cites W1941863248 @default.
• W2079149074 cites W1974768040 @default.
• W2079149074 cites W1978853688 @default.
• W2079149074 cites W1987014083 @default.
• W2079149074 cites W1990583076 @default.
• W2079149074 cites W1991735528 @default.
• W2079149074 cites W1997466909 @default.
• W2079149074 cites W2016476063 @default.
• W2079149074 cites W2052945978 @default.
• W2079149074 cites W2057338863 @default.
• W2079149074 cites W2071728536 @default.
• W2079149074 cites W2077966741 @default.
• W2079149074 cites W2084497021 @default.
• W2079149074 cites W2087140863 @default.
• W2079149074 cites W2088403248 @default.
• W2079149074 cites W2093247458 @default.
• W2079149074 cites W2101077392 @default.
• W2079149074 cites W2103947670 @default.
• W2079149074 cites W2120648989 @default.
• W2079149074 cites W2121366141 @default.
• W2079149074 cites W2158143414 @default.
• W2079149074 cites W2264494598 @default.
• W2079149074 cites W231832547 @default.
• W2079149074 cites W4240993468 @default.
• W2079149074 cites W4293775696 @default.
• W2079149074 doi "https://doi.org/10.1073/pnas.0605411103" @default.
• W2079149074 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1559777" @default.
• W2079149074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16920798" @default.
• W2079149074 hasPublicationYear "2006" @default.
• W2079149074 type Work @default.
• W2079149074 sameAs 2079149074 @default.
• W2079149074 citedByCount "58" @default.
• W2079149074 countsByYear W20791490742012 @default.
• W2079149074 countsByYear W20791490742013 @default.
• W2079149074 countsByYear W20791490742014 @default.
• W2079149074 countsByYear W20791490742015 @default.
• W2079149074 countsByYear W20791490742016 @default.
• W2079149074 countsByYear W20791490742017 @default.
• W2079149074 countsByYear W20791490742018 @default.
• W2079149074 countsByYear W20791490742020 @default.
• W2079149074 countsByYear W20791490742021 @default.
• W2079149074 countsByYear W20791490742022 @default.
• W2079149074 countsByYear W20791490742023 @default.
• W2079149074 crossrefType "journal-article" @default.
• W2079149074 hasAuthorship W2079149074A5069384522 @default.
• W2079149074 hasAuthorship W2079149074A5072355639 @default.
• W2079149074 hasBestOaLocation W20791490742 @default.
• W2079149074 hasConcept C126322002 @default.
• W2079149074 hasConcept C142724271 @default.
• W2079149074 hasConcept C184235292 @default.
• W2079149074 hasConcept C2776914184 @default.
• W2079149074 hasConcept C2779134260 @default.
• W2079149074 hasConcept C2781197716 @default.
• W2079149074 hasConcept C46762472 @default.
• W2079149074 hasConcept C502032728 @default.
• W2079149074 hasConcept C502942594 @default.
• W2079149074 hasConcept C55493867 @default.
• W2079149074 hasConcept C57074206 @default.
• W2079149074 hasConcept C71924100 @default.
• W2079149074 hasConcept C86803240 @default.
• W2079149074 hasConcept C95444343 @default.
• W2079149074 hasConceptScore W2079149074C126322002 @default.
• W2079149074 hasConceptScore W2079149074C142724271 @default.
• W2079149074 hasConceptScore W2079149074C184235292 @default.
• W2079149074 hasConceptScore W2079149074C2776914184 @default.
• W2079149074 hasConceptScore W2079149074C2779134260 @default.
• W2079149074 hasConceptScore W2079149074C2781197716 @default.
• W2079149074 hasConceptScore W2079149074C46762472 @default.
• W2079149074 hasConceptScore W2079149074C502032728 @default.
• W2079149074 hasConceptScore W2079149074C502942594 @default.
• W2079149074 hasConceptScore W2079149074C55493867 @default.
• W2079149074 hasConceptScore W2079149074C57074206 @default.
• W2079149074 hasConceptScore W2079149074C71924100 @default.
• W2079149074 hasConceptScore W2079149074C86803240 @default.
• W2079149074 hasConceptScore W2079149074C95444343 @default.
• W2079149074 hasIssue "35" @default.
• W2079149074 hasLocation W20791490741 @default.
• W2079149074 hasLocation W20791490742 @default.
• W2079149074 hasLocation W20791490743 @default.
• W2079149074 hasLocation W20791490744 @default.
• W2079149074 hasOpenAccess W2079149074 @default.
• W2079149074 hasPrimaryLocation W20791490741 @default.
• W2079149074 hasRelatedWork W1867806574 @default.
• W2079149074 hasRelatedWork W1997526132 @default.
• W2079149074 hasRelatedWork W2006915175 @default.
• W2079149074 hasRelatedWork W2014912105 @default.
• W2079149074 hasRelatedWork W2063812425 @default.
• W2079149074 hasRelatedWork W2753550874 @default.
• W2079149074 hasRelatedWork W2944072843 @default.
• W2079149074 hasRelatedWork W3031554138 @default.

• next