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- W2079150537 abstract "The dopamine system has been implicated in guiding behavior based on rewards. The pedunculopontine tegmental nucleus (PPTN) of the brainstem receives afferent inputs from reward-related structures, including the cerebral cortices and the basal ganglia, and in turn provides strong excitatory projections to dopamine neurons. This anatomical evidence predicts that PPTN neurons may carry reward information. To elucidate the functional role of the PPTN in reward-seeking behavior, we recorded single PPTN neurons while monkeys performed a visually guided saccade task in which the predicted reward value was informed by the shape of the fixation target. Two distinct groups of neurons, fixation target (FT) and reward delivery (RD) neurons, carried reward information. The activity of FT neurons persisted between FT onset and reward delivery, with the level of activity associated with the magnitude of the expected reward. RD neurons discharged phasically after reward delivery, with the levels of activity associated with the actual reward. These results suggest that separate populations of PPTN neurons signal predicted and actual reward values, both of which are necessary for the computation of reward prediction error as represented by dopamine neurons." @default.
- W2079150537 created "2016-06-24" @default.
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- W2079150537 date "2009-04-15" @default.
- W2079150537 modified "2023-10-11" @default.
- W2079150537 title "Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards" @default.
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- W2079150537 doi "https://doi.org/10.1523/jneurosci.4415-08.2009" @default.
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