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- W2079153927 abstract "Cocaine abuse represents an immense societal health and economic burden for which no effective treatment currently exists. Among the numerous intracellular signaling cascades impacted by exposure to cocaine, increased and aberrant production of pro-inflammatory cytokines in the CNS has been observed. Additionally, we have previously reported a decrease in retinoid-X-receptor-gamma (RXR-γ) in brains of mice chronically exposed to cocaine. Through obligate heterodimerization with a number of nuclear receptors, RXRs serve as master regulatory transcription factors, which can potentiate or suppress expression of a wide spectrum of genes. Little is known about the regulation of RXR levels, but previous studies indicate cellular stressors such as cytokines negatively regulate levels of RXRs in vitro. To evaluate the mechanism underlying the cocaine-induced decreases in RXR-γ levels observed in vivo, we exposed neurons to cocaine in vitro and examined pathways which may contribute to disruption in RXR signaling, including activation of stress pathways by cytokine induction. In these studies, we provide the first evidence that cocaine exposure disrupts neuronal RXR-γ signaling in vitro by promoting its nuclear export and degradation. Furthermore, we demonstrate this effect may be mediated, at least in part, by cocaine-induced production of TNF-α and its downstream effector c-Jun-NH-terminal kinase (JNK). Findings from this study are therefore applicable to both cocaine abuse and to pathological conditions characterized by neuroinflammatory factors, such as neurodegenerative disease." @default.
- W2079153927 created "2016-06-24" @default.
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- W2079153927 creator A5029732677 @default.
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- W2079153927 creator A5056179791 @default.
- W2079153927 date "2015-01-14" @default.
- W2079153927 modified "2023-09-27" @default.
- W2079153927 title "Cocaine Induces Nuclear Export and Degradation of Neuronal Retinoid X Receptor-γ via a TNF-α/JNK- Mediated Mechanism" @default.
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- W2079153927 doi "https://doi.org/10.1007/s11481-014-9573-x" @default.
- W2079153927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4336643" @default.
- W2079153927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25586717" @default.
- W2079153927 hasPublicationYear "2015" @default.
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