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- W2079154129 abstract "Male Wistar rats were starved for 24 h before being injected with insulin (Novo Actrapid®) in a dose of 40 Iukg-1 i.p. They were then anesthetized with 2–3% halothane, tracheotomized, immobilized with tubo-curarine chloride (1.5 mg-kg-1, i.v.) and connected to a respirator delivering nitrous oxide-oxygen (3:1). Femoral arterial catheters were inserted for blood pressure recording and blood sampling, and a femoral vein was cannulated for infusions. Goldplated screws were inserted in the skull bone for frontoparietal recording of EEG. Arterial PCO2was adjusted to 35–40 mmHg and body temperature was maintained close to 37oC. Local cerebral blood flow (1-CBF) was measured with the autoradiographic 14C-iodoantipyrine technique of Sakurada et al. (1978) as described in detail in a previous communication (Abdul-Rahman et al. 1979). Measurements were performed in animals in which the spontaneous EEG activity had ceased for 30 min, as well as in those that had been allowed recovery periods of either 5, 30 or 90 min. Recovery was induced by i.v. injection of 0.5 ml of a 50% (w/v) glucose solution in saline followed by i.v. infusion (1 ml/h)." @default.
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- W2079154129 date "1979-07-01" @default.
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- W2079154129 title "Delayed hypoperfusion in the cerebral cortex of the rat in the recovery period following severe hypoglycemia" @default.
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- W2079154129 doi "https://doi.org/10.1111/j.1748-1716.1979.tb06413.x" @default.
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