FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079157098> ?p ?o ?g. }

• W2079157098 endingPage "73" @default.
• W2079157098 startingPage "68" @default.
• W2079157098 abstract "The in vitro geno- and cytotoxicity exerted by the N-methylcarbamate pesticide carbofuran (CF) and its commercial formulation furadan (F) were studied in Chinese hamster ovary (CHO(K1)) cells by several bioassays for both genotoxicity (e.g., the sister chromatid exchange (SCE) and micronuclei (MNi) frequencies), and cytotoxicity (e.g., cell-cycle progression, mitotic index (MI), 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), and neutral red (NR)). Both CF and F activities were tested within the range of 5-100 microg/ml. CF within a 10-100 microg/ml concentration-range induced a significant dependent increase of SCE frequency and MNi over control values. At the same concentration-range, F increased significantly the SCE frequencies over control values although in a non-dependent manner while only an enhanced frequency of MNi was found in those 50 microg/ml-treated cultures. No binucleated cytokinesis-block cells were found in 100 microg/ml F-treated cultures. The NDI index revealed a delay in the onset of cell-division with 50 and 100 microg/ml of CF and F, respectively. The delayed rate of nuclear division induced by 100 microg/ml of F was higher than that induced by an equal concentration of CF. CF and F induced both a significant concentration-dependent delay in cell-cycle progression and a decrease in the proliferative replication index within 5-100 microg/ml and 50-100 microg/ml concentration-range, respectively. Decreased cell viability was found in up to 26% and 47% in 100 microg/ml CF- and F-treated cultures, respectively. The NR and MTT assays revealed a clear cell growth inhibition when concentrations of 50 and 100 microg/ml of either CF or F were employed. Accordingly, the results highlight that CF by itself and F, even in a greater extend exerts both genotoxicity and cytotoxicity in mammalian cells in culture, at least in CHOK1 cells." @default.
• W2079157098 created "2016-06-24" @default.
• W2079157098 creator A5010155246 @default.
• W2079157098 creator A5013837135 @default.
• W2079157098 creator A5031962646 @default.
• W2079157098 creator A5041054925 @default.
• W2079157098 creator A5049780260 @default.
• W2079157098 date "2008-10-01" @default.
• W2079157098 modified "2023-10-01" @default.
• W2079157098 title "Genotoxic and cytotoxic effects of carbofuran and furadan® on Chinese hamster ovary (CHOK1) cells" @default.
• W2079157098 cites W1971787114 @default.
• W2079157098 cites W1972649937 @default.
• W2079157098 cites W1976454097 @default.
• W2079157098 cites W1984765188 @default.
• W2079157098 cites W1989160003 @default.
• W2079157098 cites W1994016816 @default.
• W2079157098 cites W1995277333 @default.
• W2079157098 cites W1995442490 @default.
• W2079157098 cites W1995654282 @default.
• W2079157098 cites W1997680902 @default.
• W2079157098 cites W2007295046 @default.
• W2079157098 cites W2009554951 @default.
• W2079157098 cites W2018133082 @default.
• W2079157098 cites W2021331786 @default.
• W2079157098 cites W2023796675 @default.
• W2079157098 cites W2024264346 @default.
• W2079157098 cites W2028045940 @default.
• W2079157098 cites W2031053072 @default.
• W2079157098 cites W2034285915 @default.
• W2079157098 cites W2040525136 @default.
• W2079157098 cites W2053551033 @default.
• W2079157098 cites W2058503820 @default.
• W2079157098 cites W2068791315 @default.
• W2079157098 cites W2081288385 @default.
• W2079157098 cites W2088686339 @default.
• W2079157098 cites W2098883242 @default.
• W2079157098 cites W2112602788 @default.
• W2079157098 cites W2118432477 @default.
• W2079157098 cites W2123148892 @default.
• W2079157098 cites W2124318306 @default.
• W2079157098 cites W2137254278 @default.
• W2079157098 cites W2943555153 @default.
• W2079157098 cites W39614084 @default.
• W2079157098 cites W4211007234 @default.
• W2079157098 cites W4239073591 @default.
• W2079157098 cites W4251364490 @default.
• W2079157098 cites W65325649 @default.
• W2079157098 doi "https://doi.org/10.1016/j.mrgentox.2008.07.007" @default.
• W2079157098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18706518" @default.
• W2079157098 hasPublicationYear "2008" @default.
• W2079157098 type Work @default.
• W2079157098 sameAs 2079157098 @default.
• W2079157098 citedByCount "45" @default.
• W2079157098 countsByYear W20791570982012 @default.
• W2079157098 countsByYear W20791570982013 @default.
• W2079157098 countsByYear W20791570982014 @default.
• W2079157098 countsByYear W20791570982015 @default.
• W2079157098 countsByYear W20791570982016 @default.
• W2079157098 countsByYear W20791570982019 @default.
• W2079157098 countsByYear W20791570982020 @default.
• W2079157098 countsByYear W20791570982021 @default.
• W2079157098 countsByYear W20791570982022 @default.
• W2079157098 countsByYear W20791570982023 @default.
• W2079157098 crossrefType "journal-article" @default.
• W2079157098 hasAuthorship W2079157098A5010155246 @default.
• W2079157098 hasAuthorship W2079157098A5013837135 @default.
• W2079157098 hasAuthorship W2079157098A5031962646 @default.
• W2079157098 hasAuthorship W2079157098A5041054925 @default.
• W2079157098 hasAuthorship W2079157098A5049780260 @default.
• W2079157098 hasConcept C109316439 @default.
• W2079157098 hasConcept C143016879 @default.
• W2079157098 hasConcept C153911025 @default.
• W2079157098 hasConcept C16685009 @default.
• W2079157098 hasConcept C175656101 @default.
• W2079157098 hasConcept C178790620 @default.
• W2079157098 hasConcept C185592680 @default.
• W2079157098 hasConcept C190283241 @default.
• W2079157098 hasConcept C202751555 @default.
• W2079157098 hasConcept C2778959862 @default.
• W2079157098 hasConcept C2779071816 @default.
• W2079157098 hasConcept C2780484033 @default.
• W2079157098 hasConcept C29537977 @default.
• W2079157098 hasConcept C29730261 @default.
• W2079157098 hasConcept C33070731 @default.
• W2079157098 hasConcept C36681516 @default.
• W2079157098 hasConcept C45080847 @default.
• W2079157098 hasConcept C54355233 @default.
• W2079157098 hasConcept C55493867 @default.
• W2079157098 hasConcept C66640590 @default.
• W2079157098 hasConcept C71924100 @default.
• W2079157098 hasConcept C81885089 @default.
• W2079157098 hasConcept C86803240 @default.
• W2079157098 hasConcept C93304396 @default.
• W2079157098 hasConceptScore W2079157098C109316439 @default.
• W2079157098 hasConceptScore W2079157098C143016879 @default.
• W2079157098 hasConceptScore W2079157098C153911025 @default.
• W2079157098 hasConceptScore W2079157098C16685009 @default.
• W2079157098 hasConceptScore W2079157098C175656101 @default.

• next