Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079161708> ?p ?o ?g. }
- W2079161708 endingPage "468" @default.
- W2079161708 startingPage "458" @default.
- W2079161708 abstract "Abstract Conformational transitions are thought to be the prime mechanism of prion diseases. In this study, the energy landscapes of a wild‐type prion protein (PrP) and the D178N and E200K mutant proteins were mapped, enabling the characterization of the normal isoforms (PrP C ) and partially unfolded isoforms (PrP PU ) of the three prion protein analogs. It was found that the three energy landscapes differ in three respects: (i) the relative stability of the PrP C and the PrP PU states, (ii) the transition pathways from PrP C to PrP PU , and (iii) the relative stability of the three helices in the PrP C state. In particular, it was found that although helix 1 (residues 144‐156) is the most stable helix in wild‐type PrP, its stability is dramatically reduced by both mutations. This destabilization is due to changes in the charge distribution that affects the internal salt bridges responsible for the greater stability of this helix in wild‐type PrP. Although both mutations result in similar destabilization of helix 1, they a have different effect on the overall stability of PrP C and of PrP PU isoforms and on structural properties. The destabilization of helix 1 by mutations provides additional evidences to the role of this helix in the pathogenic transition from the PrP C to the pathogenic isoform PrP SC . Proteins 2002;47:458–468. © 2002 Wiley‐Liss, Inc." @default.
- W2079161708 created "2016-06-24" @default.
- W2079161708 creator A5054904960 @default.
- W2079161708 creator A5067242372 @default.
- W2079161708 date "2002-04-10" @default.
- W2079161708 modified "2023-10-18" @default.
- W2079161708 title "Conformational polymorphism of wild-type and mutant prion proteins: Energy landscape analysis" @default.
- W2079161708 cites W131363548 @default.
- W2079161708 cites W1494971749 @default.
- W2079161708 cites W1546306335 @default.
- W2079161708 cites W1637145043 @default.
- W2079161708 cites W1964249554 @default.
- W2079161708 cites W1966171026 @default.
- W2079161708 cites W1976561697 @default.
- W2079161708 cites W1977428203 @default.
- W2079161708 cites W1980125299 @default.
- W2079161708 cites W1983634635 @default.
- W2079161708 cites W1990706450 @default.
- W2079161708 cites W1999301383 @default.
- W2079161708 cites W2001763373 @default.
- W2079161708 cites W2005687845 @default.
- W2079161708 cites W2008708467 @default.
- W2079161708 cites W2017109525 @default.
- W2079161708 cites W2020388963 @default.
- W2079161708 cites W2022392367 @default.
- W2079161708 cites W2027062533 @default.
- W2079161708 cites W2027408247 @default.
- W2079161708 cites W2029699793 @default.
- W2079161708 cites W2030103154 @default.
- W2079161708 cites W2030332033 @default.
- W2079161708 cites W2032843390 @default.
- W2079161708 cites W2035307175 @default.
- W2079161708 cites W2036548578 @default.
- W2079161708 cites W2047289990 @default.
- W2079161708 cites W2048041842 @default.
- W2079161708 cites W2048125591 @default.
- W2079161708 cites W2048652707 @default.
- W2079161708 cites W2049627175 @default.
- W2079161708 cites W2052022742 @default.
- W2079161708 cites W2052610951 @default.
- W2079161708 cites W2061921767 @default.
- W2079161708 cites W2063401839 @default.
- W2079161708 cites W2064602319 @default.
- W2079161708 cites W2066010782 @default.
- W2079161708 cites W2073055599 @default.
- W2079161708 cites W2075702662 @default.
- W2079161708 cites W2076146345 @default.
- W2079161708 cites W2078656522 @default.
- W2079161708 cites W2094795801 @default.
- W2079161708 cites W2095705484 @default.
- W2079161708 cites W2109401365 @default.
- W2079161708 cites W2119141718 @default.
- W2079161708 cites W2124782672 @default.
- W2079161708 cites W2124907927 @default.
- W2079161708 cites W2134731229 @default.
- W2079161708 cites W2138768135 @default.
- W2079161708 cites W2143795630 @default.
- W2079161708 cites W2152958744 @default.
- W2079161708 cites W2158476854 @default.
- W2079161708 cites W2162166182 @default.
- W2079161708 cites W2167564565 @default.
- W2079161708 cites W2340182873 @default.
- W2079161708 cites W614018474 @default.
- W2079161708 doi "https://doi.org/10.1002/prot.10095" @default.
- W2079161708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12001224" @default.
- W2079161708 hasPublicationYear "2002" @default.
- W2079161708 type Work @default.
- W2079161708 sameAs 2079161708 @default.
- W2079161708 citedByCount "32" @default.
- W2079161708 countsByYear W20791617082012 @default.
- W2079161708 countsByYear W20791617082013 @default.
- W2079161708 countsByYear W20791617082014 @default.
- W2079161708 countsByYear W20791617082018 @default.
- W2079161708 countsByYear W20791617082021 @default.
- W2079161708 countsByYear W20791617082022 @default.
- W2079161708 crossrefType "journal-article" @default.
- W2079161708 hasAuthorship W2079161708A5054904960 @default.
- W2079161708 hasAuthorship W2079161708A5067242372 @default.
- W2079161708 hasConcept C104317684 @default.
- W2079161708 hasConcept C119621388 @default.
- W2079161708 hasConcept C12554922 @default.
- W2079161708 hasConcept C142724271 @default.
- W2079161708 hasConcept C143065580 @default.
- W2079161708 hasConcept C185592680 @default.
- W2079161708 hasConcept C18903297 @default.
- W2079161708 hasConcept C207583985 @default.
- W2079161708 hasConcept C2778530040 @default.
- W2079161708 hasConcept C2779134260 @default.
- W2079161708 hasConcept C2779965526 @default.
- W2079161708 hasConcept C2988375501 @default.
- W2079161708 hasConcept C3019804061 @default.
- W2079161708 hasConcept C47701112 @default.
- W2079161708 hasConcept C53345823 @default.
- W2079161708 hasConcept C55493867 @default.
- W2079161708 hasConcept C71924100 @default.
- W2079161708 hasConcept C86803240 @default.
- W2079161708 hasConceptScore W2079161708C104317684 @default.
- W2079161708 hasConceptScore W2079161708C119621388 @default.