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• W2079162521 abstract "The CCR5 chemokine receptor plays a crucial role in the initiation ofin vivoHIV infection, acting as a critical coreceptor molecule for primary strains. Individuals with mutations in the CCR5 gene that reduce its level of expression are resistant to HIV-1 infection. Since these mutations are not associated with any known clinical condition, CCR5 may be an ideal target for anti-HIV therapy. We have designed an artificial hammerhead ribozyme, denoted RzR5-76, targeted to exon 2 of the human CCR5 mRNA. When RzR5-76 activity is induced in HEK 293 cells transfected with a CCR5 expression plasmid, the surface levels of this chemokine receptor are reduced up to 60%. The results indicate that this inhibitory effect is mainly due to the catalytic activity of the ribozyme and not to its antisense properties. These preliminary data suggest that intracellular ribozymes could be usedin vivoto block HIV-1 entry into human cells." @default.
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• W2079162521 date "1998-10-01" @default.
• W2079162521 modified "2023-09-26" @default.
• W2079162521 title "A Hammerhead Ribozyme Targeted to the Human Chemokine Receptor CCR5" @default.
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• W2079162521 doi "https://doi.org/10.1006/bbrc.1998.9522" @default.
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