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- W2079162583 abstract "The B cell non-Hodgkin's lymphomas (NHL-B) are a common, but heterogeneous group of human lymphoid neoplasms, consisting of monoclonal populations of neoplastic B lymphocytes demonstrating non-random chromosomal abnormalities, often associated with proto-oncogene translocations. Clinically and pathologically, these lymphomas are classified as low, intermediate, or high grade, according to the clinical aggressiveness of the NHL-B subtype. The clinical behavior can also be correlated with biological function regarding proliferative capabilities of the tumor cells. Our studies have shown that the low grade B cell lymphomas have low constitutive proliferative capacity in vitro and do not respond to cytokine growth factors (CGF), while the high grade NHL-B respond to the B cell growth factor (BCGF) family of CGFs. The high grade NHL-B also secrete BCGFs both in vitro and in vivo, as autocrine growth factors that may provide a target for new therapeutic approaches to therapy." @default.
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- W2079162583 date "1993-01-01" @default.
- W2079162583 modified "2023-10-16" @default.
- W2079162583 title "Human B Cell Lymphomas:In VitroandIn VivoStudies on Growth Factors and Cell Growth" @default.
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- W2079162583 doi "https://doi.org/10.3109/10428199309149112" @default.
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