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• W2079163635 abstract "The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4+ and CD8+ T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8+ cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8+ T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients." @default.
• W2079163635 created "2016-06-24" @default.
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• W2079163635 date "2012-07-01" @default.
• W2079163635 modified "2023-10-17" @default.
• W2079163635 title "Increased Program Cell Death–1 Expression on T Lymphocytes of Patients With Progressive Multifocal Leukoencephalopathy" @default.
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• W2079163635 doi "https://doi.org/10.1097/qai.0b013e31825a313c" @default.
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