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- W2079163709 abstract "Twenty-nine adolescents with Major Depressive Disorder were treated with imipramine on a t.i.d. dosage schedule for 3 weeks titrating to a maximal 5.0 mg/kg/day as limited by side effects (X = 4.5 ± 0.7). They were then randomly divided into two groups: 16 received their total dose at 10 P.M., after standard divided doses at 7 A.M. and 3 P.M. that same day, and then no more imipramine during the subsequent 24 hours, whereas 13 continued t.i.d. dosage. EKG and plasma TCA levels in both groups were serially examined over the next 24 hours. There were no significant differences between groups in the per subject means or maxima of any EKG parameter. These data suggest that a once daily dosage schedule for imipramine is safe in adolescents once they are at steady rate. Although there was a strong relationship between the tricyclic plasma levels and EKG parameters throughout the day, EKG parameters cannot be used to predict plasma levels—there was wide variation in this relationship between individuals, and even within individual adolescents the plasma level could change over a wide range without any change in EKG parameters." @default.
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- W2079163709 date "1987-05-01" @default.
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- W2079163709 title "Relative Safety of Single Versus Divided Dose Imipramine in Adolescent Major Depression" @default.
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- W2079163709 doi "https://doi.org/10.1097/00004583-198705000-00021" @default.
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