FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079166587> ?p ?o ?g. }

• W2079166587 endingPage "F853" @default.
• W2079166587 startingPage "F846" @default.
• W2079166587 abstract "During systemic acidosis, renal proximal tubular cells exhibit enhanced rates of bicarbonate and ammonium ion synthesis and undergo extensive hypertrophy. The former adaptations are accomplished, in part, by increased expression of glutaminase (GA). LLC-PK(1)-FBPase+ cells, a gluconeogenic line of porcine kidney cells, exhibit a rapid activation of the ERK1/2 and p38 MAPK pathways and a two- to threefold increase in GA mRNA when transferred to acidic medium (pH 6.9). Transforming growth factor-beta (TGF-beta), a potent activator of MAPK and Smad signaling cascades, also causes extensive renal hypertrophy. Thus the potential role of TGF-beta in the renal response to metabolic acidosis was investigated. Western blot analyses established that in LLC-PK(1)-FBPase+ cells, TGF-beta activated the ERK1/2, p38 MAPK, and Smad1/5/8 pathways, but not the JNK and Smad2/3 pathways. Addition of TGF-beta to cells cultured in normal medium (pH 7.4) produced a steady increase in GA mRNA, resulting in a twofold induction after 18 h. Western blot analysis indicated that treatment with either TGF-beta or acidic medium resulted in an increased level of fibronectin. However, the effects of the two treatments on both GA mRNA and fibronectin levels occurred with different time courses and were additive. In addition, the rates of ammonia production were decreased slightly by addition of TGF-beta. Finally, a GA-luciferase reporter construct, which is activated 3.5-fold by treatment with acidic medium, is not affected by TGF-beta. Therefore, TGF-beta and metabolic acidosis activate some of the same signaling pathways in LLC-PK(1)-FBPase+ cells, but produce separate effects on GA expression." @default.
• W2079166587 created "2016-06-24" @default.
• W2079166587 creator A5002340220 @default.
• W2079166587 creator A5015043722 @default.
• W2079166587 creator A5047409791 @default.
• W2079166587 creator A5059240494 @default.
• W2079166587 creator A5059385549 @default.
• W2079166587 creator A5075740587 @default.
• W2079166587 creator A5083181792 @default.
• W2079166587 date "2007-09-01" @default.
• W2079166587 modified "2023-09-24" @default.
• W2079166587 title "TGF-β signaling and its effect on glutaminase expression in LLC-PK₁-FBPase⁺cells" @default.
• W2079166587 cites W1225710252 @default.
• W2079166587 cites W1609684706 @default.
• W2079166587 cites W1636022999 @default.
• W2079166587 cites W1840163537 @default.
• W2079166587 cites W1963864987 @default.
• W2079166587 cites W1968858315 @default.
• W2079166587 cites W1970129719 @default.
• W2079166587 cites W1995680472 @default.
• W2079166587 cites W1996559098 @default.
• W2079166587 cites W2005792688 @default.
• W2079166587 cites W2008019124 @default.
• W2079166587 cites W2018454809 @default.
• W2079166587 cites W2027584098 @default.
• W2079166587 cites W2030279034 @default.
• W2079166587 cites W2033553634 @default.
• W2079166587 cites W2035653659 @default.
• W2079166587 cites W2041614750 @default.
• W2079166587 cites W2045141910 @default.
• W2079166587 cites W2046881052 @default.
• W2079166587 cites W2051540590 @default.
• W2079166587 cites W2051607654 @default.
• W2079166587 cites W2059657580 @default.
• W2079166587 cites W2077767249 @default.
• W2079166587 cites W2082438422 @default.
• W2079166587 cites W2082760271 @default.
• W2079166587 cites W2084662323 @default.
• W2079166587 cites W2091822932 @default.
• W2079166587 cites W2099368049 @default.
• W2079166587 cites W2101051256 @default.
• W2079166587 cites W2122712691 @default.
• W2079166587 cites W2132803823 @default.
• W2079166587 cites W2134268527 @default.
• W2079166587 cites W2145407987 @default.
• W2079166587 cites W2153454102 @default.
• W2079166587 cites W2154568166 @default.
• W2079166587 cites W2154601080 @default.
• W2079166587 cites W2158075507 @default.
• W2079166587 cites W2167928512 @default.
• W2079166587 cites W2172007677 @default.
• W2079166587 cites W2181819155 @default.
• W2079166587 cites W2184119781 @default.
• W2079166587 cites W2263913332 @default.
• W2079166587 cites W2282237640 @default.
• W2079166587 cites W2403158809 @default.
• W2079166587 doi "https://doi.org/10.1152/ajprenal.00139.2007" @default.
• W2079166587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17596530" @default.
• W2079166587 hasPublicationYear "2007" @default.
• W2079166587 type Work @default.
• W2079166587 sameAs 2079166587 @default.
• W2079166587 citedByCount "11" @default.
• W2079166587 countsByYear W20791665872012 @default.
• W2079166587 countsByYear W20791665872013 @default.
• W2079166587 countsByYear W20791665872014 @default.
• W2079166587 countsByYear W20791665872016 @default.
• W2079166587 countsByYear W20791665872018 @default.
• W2079166587 countsByYear W20791665872021 @default.
• W2079166587 crossrefType "journal-article" @default.
• W2079166587 hasAuthorship W2079166587A5002340220 @default.
• W2079166587 hasAuthorship W2079166587A5015043722 @default.
• W2079166587 hasAuthorship W2079166587A5047409791 @default.
• W2079166587 hasAuthorship W2079166587A5059240494 @default.
• W2079166587 hasAuthorship W2079166587A5059385549 @default.
• W2079166587 hasAuthorship W2079166587A5075740587 @default.
• W2079166587 hasAuthorship W2079166587A5083181792 @default.
• W2079166587 hasConcept C104317684 @default.
• W2079166587 hasConcept C109549099 @default.
• W2079166587 hasConcept C118131993 @default.
• W2079166587 hasConcept C126322002 @default.
• W2079166587 hasConcept C134018914 @default.
• W2079166587 hasConcept C153911025 @default.
• W2079166587 hasConcept C184235292 @default.
• W2079166587 hasConcept C185592680 @default.
• W2079166587 hasConcept C2776415932 @default.
• W2079166587 hasConcept C2779349466 @default.
• W2079166587 hasConcept C2781080636 @default.
• W2079166587 hasConcept C515207424 @default.
• W2079166587 hasConcept C55493867 @default.
• W2079166587 hasConcept C57074206 @default.
• W2079166587 hasConcept C71924100 @default.
• W2079166587 hasConcept C86803240 @default.
• W2079166587 hasConceptScore W2079166587C104317684 @default.
• W2079166587 hasConceptScore W2079166587C109549099 @default.
• W2079166587 hasConceptScore W2079166587C118131993 @default.
• W2079166587 hasConceptScore W2079166587C126322002 @default.
• W2079166587 hasConceptScore W2079166587C134018914 @default.
• W2079166587 hasConceptScore W2079166587C153911025 @default.

• next