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• W2079167470 abstract "The goal of these studies was to analyze the ability of androstenediol (AED) to counter-regulate the influences of stress on anti-viral immune responses. Male C57BL/6 mice, treated with 320 mg/kg AED were infected with influenza virus and subjected to repeated cycles of restraint (RST). AED blocked RST-mediated suppression of cell recruitment to the draining lymph node, lung NK cell activity, and CD4 + T cell activation. In addition, mice treated with AED had lower pre-corticosterone levels as compared to vehicle controls and the RST-mediated elevation of corticosterone was significantly blunted by AED treatment. These data suggest that AED functions to augment anti-viral immune responses by counter-regulating glucocorticoid function." @default.
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• W2079167470 date "1999-08-01" @default.
• W2079167470 modified "2023-09-27" @default.
• W2079167470 title "Androstenediol (AED) prevents neuroendocrine-mediated suppression of the immune response to an influenza viral infection" @default.
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• W2079167470 doi "https://doi.org/10.1016/s0165-5728(99)00068-5" @default.
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