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• W2079169175 abstract "Transmission ratio distortion (TRD) and sterility are male-specific quantitative trait phenomena associated with the mouse t haplotype. TRD occurs in t haplotype-heterozygous males and is caused by the deleterious action of distorter products on sperm bearing a wild-type responder locus. It has been proposed that t-mediated male sterility is a severe manifestation of TRD caused by homozygosity for distorter loci; thus, the distorter and sterility loci would be identical. In this, study a transgenic approach was used to identify the proximal sterility locus, tcs1 (S1), and test its role in TRD. Mice transgenic for a wild-type bacterial artificial chromosome (BAC) derived from the S1-critical region were bred onto t haplotype backgrounds. Mating results conclusively showed that the BAC is sufficient to restore fertility in otherwise sterile males. Multiple mutations were identified in the t alleles of Synj2 and Serac1, two genes in the BAC; thus, they are candidates for S1. In addition, whereas the BAC transgene rescued sterility, it had no effect on TRD. These results uncouple the proximal t haplotype sterility locus, S1, from TRD, demonstrating that S1 and the proximal distorter locus, D1, are not the same gene." @default.
• W2079169175 created "2016-06-24" @default.
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• W2079169175 creator A5085071991 @default.
• W2079169175 date "2005-02-18" @default.
• W2079169175 modified "2023-10-18" @default.
• W2079169175 title "Mutations in <i>Serac1</i> or <i>Synj2</i> cause proximal <i>t</i> haplotype-mediated male mouse sterility but not transmission ratio distortion" @default.
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• W2079169175 doi "https://doi.org/10.1073/pnas.0407970102" @default.
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