FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079169184> ?p ?o ?g. }

• W2079169184 endingPage "202" @default.
• W2079169184 startingPage "193" @default.
• W2079169184 abstract "Gonadotropin secretion by the pituitary gland is under the control of luteinizing hormone-releasing hormone (LHRH) and the putative follicle-stimulating hormone-releasing factor (FSHRF). Lamprey III LHRH is a potent FSHRF in the rat and appears to be resident in the FSH controlling area of the rat hypothalamus. It is an analog of mammalian LHRH and may be the long-sought FSHRF. Gonadal steroids feedback at hypothalamic and pituitary levels to either inhibit or stimulate the release of LH and FSH, which is also affected by inhibin and activin secreted by the gonads. Important control is exercised by acetylcholine, norepinephrine (NE), dopamine, serotonin, melatonin and glutamic acid (GA). Furthermore, LH and FSH also act at the hypothalamic level to alter secretion of gonadotropins. More recently, growth factors have been shown to have an important role. Many peptides act to inhibit or increase release of LH, and the sign of their action is often reversed by estrogen. A number of cytokines act at the hypothalamic level to suppress acutely the release of LH but not FSH. NE, GA and oxytocin stimulate LHRH release by activation of neural nitric oxide synthase (nNOS). The pathway is as follows: oxytocin and/or GA activate NE neurons in the medial basal hypothalamus (MBH) that activate NOergic neurons by α₁ receptors. The NO released diffuses into LHRH terminals and induces LHRH release by activation of guanylate cyclase (GC) and cyclooxygenase. NO not only controls release of LHRH bound for the pituitary, but also that which induces mating by actions in the brain stem. An exciting recent development has been the discovery of the adipocyte hormone, leptin, a cytokine related to tumor necrosis factor-α (TNF-α). In the male rat, leptin exhibits a high potency to stimulate FSH and LH release from hemipituitaries incubated in vitro, and increases the release of LHRH from MBH explants by stimulating the release of NO. LHRH and leptin release LH by activation of NOS in the gonadotropes. The NO released activates GC that releases cyclic GMP which induces LH release. Leptin induces LH release in conscious, ovariectomized estrogen-primed female rats, presumably by stimulating LHRH release. At the effective dose of estrogen to activate LH release, FSH release is inhibited. Leptin may play an important role in induction of puberty and control of LHRH release in the adult as well." @default.
• W2079169184 created "2016-06-24" @default.
• W2079169184 creator A5020617181 @default.
• W2079169184 creator A5024970198 @default.
• W2079169184 creator A5025033565 @default.
• W2079169184 creator A5064857788 @default.
• W2079169184 creator A5069185819 @default.
• W2079169184 creator A5084068739 @default.
• W2079169184 date "1998-01-01" @default.
• W2079169184 modified "2023-10-16" @default.
• W2079169184 title "Hypothalamic Control of FSH and LH by FSH-RF, LHRH, Cytokines, Leptin and Nitric Oxide" @default.
• W2079169184 cites W1971213778 @default.
• W2079169184 cites W1981762970 @default.
• W2079169184 cites W1984397256 @default.
• W2079169184 cites W1990804226 @default.
• W2079169184 cites W1991577682 @default.
• W2079169184 cites W2013215898 @default.
• W2079169184 cites W2020739416 @default.
• W2079169184 cites W2033933815 @default.
• W2079169184 cites W2043359018 @default.
• W2079169184 cites W2055956383 @default.
• W2079169184 cites W2073828263 @default.
• W2079169184 cites W2081025102 @default.
• W2079169184 cites W2115310479 @default.
• W2079169184 cites W4253093097 @default.
• W2079169184 doi "https://doi.org/10.1159/000026337" @default.
• W2079169184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9730686" @default.
• W2079169184 hasPublicationYear "1998" @default.
• W2079169184 type Work @default.
• W2079169184 sameAs 2079169184 @default.
• W2079169184 citedByCount "51" @default.
• W2079169184 countsByYear W20791691842012 @default.
• W2079169184 countsByYear W20791691842013 @default.
• W2079169184 countsByYear W20791691842015 @default.
• W2079169184 countsByYear W20791691842016 @default.
• W2079169184 countsByYear W20791691842022 @default.
• W2079169184 crossrefType "journal-article" @default.
• W2079169184 hasAuthorship W2079169184A5020617181 @default.
• W2079169184 hasAuthorship W2079169184A5024970198 @default.
• W2079169184 hasAuthorship W2079169184A5025033565 @default.
• W2079169184 hasAuthorship W2079169184A5064857788 @default.
• W2079169184 hasAuthorship W2079169184A5069185819 @default.
• W2079169184 hasAuthorship W2079169184A5084068739 @default.
• W2079169184 hasConcept C118303440 @default.
• W2079169184 hasConcept C126322002 @default.
• W2079169184 hasConcept C134018914 @default.
• W2079169184 hasConcept C170493617 @default.
• W2079169184 hasConcept C185592680 @default.
• W2079169184 hasConcept C197012351 @default.
• W2079169184 hasConcept C2776176026 @default.
• W2079169184 hasConcept C2777003273 @default.
• W2079169184 hasConcept C2778575703 @default.
• W2079169184 hasConcept C2778782382 @default.
• W2079169184 hasConcept C2778894405 @default.
• W2079169184 hasConcept C2779279165 @default.
• W2079169184 hasConcept C71315377 @default.
• W2079169184 hasConcept C71924100 @default.
• W2079169184 hasConcept C86803240 @default.
• W2079169184 hasConceptScore W2079169184C118303440 @default.
• W2079169184 hasConceptScore W2079169184C126322002 @default.
• W2079169184 hasConceptScore W2079169184C134018914 @default.
• W2079169184 hasConceptScore W2079169184C170493617 @default.
• W2079169184 hasConceptScore W2079169184C185592680 @default.
• W2079169184 hasConceptScore W2079169184C197012351 @default.
• W2079169184 hasConceptScore W2079169184C2776176026 @default.
• W2079169184 hasConceptScore W2079169184C2777003273 @default.
• W2079169184 hasConceptScore W2079169184C2778575703 @default.
• W2079169184 hasConceptScore W2079169184C2778782382 @default.
• W2079169184 hasConceptScore W2079169184C2778894405 @default.
• W2079169184 hasConceptScore W2079169184C2779279165 @default.
• W2079169184 hasConceptScore W2079169184C71315377 @default.
• W2079169184 hasConceptScore W2079169184C71924100 @default.
• W2079169184 hasConceptScore W2079169184C86803240 @default.
• W2079169184 hasIssue "3-4" @default.
• W2079169184 hasLocation W20791691841 @default.
• W2079169184 hasLocation W20791691842 @default.
• W2079169184 hasOpenAccess W2079169184 @default.
• W2079169184 hasPrimaryLocation W20791691841 @default.
• W2079169184 hasRelatedWork W1981222718 @default.
• W2079169184 hasRelatedWork W1986415250 @default.
• W2079169184 hasRelatedWork W2024100619 @default.
• W2079169184 hasRelatedWork W2033315361 @default.
• W2079169184 hasRelatedWork W2045160985 @default.
• W2079169184 hasRelatedWork W2071502919 @default.
• W2079169184 hasRelatedWork W2076655884 @default.
• W2079169184 hasRelatedWork W2134449442 @default.
• W2079169184 hasRelatedWork W2147069408 @default.
• W2079169184 hasRelatedWork W2213723245 @default.
• W2079169184 hasVolume "5" @default.
• W2079169184 isParatext "false" @default.
• W2079169184 isRetracted "false" @default.
• W2079169184 magId "2079169184" @default.
• W2079169184 workType "article" @default.