FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079174302> ?p ?o ?g. }

• W2079174302 endingPage "454" @default.
• W2079174302 startingPage "447" @default.
• W2079174302 abstract "Abstract Exposure of primary cultures of cerebellar granule cells for 15 min to micromolar concentrations of glutamate results in cell death of both necrotic and apoptotic types. Among the intracellular events triggered by glutamate, we identified two transcriptional factors: the p50 member of the NF‐ κ B family and the tumor suppressor phosphoprotein p53. Pretreatment of the cultures with aspirin, which inhibits NF‐ κ B activation, or with specific p53 antisense oligonucleotide, which inhibits p53 transcription, resulted in a complete prevention of glutamate‐induced p53 induction and apoptosis. These findings suggest the existence of a transcriptional program activated by glutamate receptor stimulation in which p50 and p53 play a relevant role. Then, we studied the expression of two p53 downstream genes that could participate in the glutamate‐induced pro‐apoptotic pathway: p21, which codes for an inhibitor of different cyclin dependent kinases, and MSH2, which codes for a protein involved in the recognition and repair of DNA mismatches. We found that primary cerebellar neurons expressed p21 and MSH2 at very low levels in basal conditions. However, very soon after a brief exposure of the cells to glutamate, the expression of both proteins was dramatically enhanced. On these bases, we propose NF‐ κ B, p53, p21 and MSH2 as relevant contributors of the glutamate‐induced pro‐apoptotic pathway. Understanding this cascade of nuclear events may unravel specific targets for pharmacological intervention for those neurological diseases in which excitatory amino acid‐induced apoptosis plays a relevant role." @default.
• W2079174302 created "2016-06-24" @default.
• W2079174302 creator A5023788664 @default.
• W2079174302 creator A5074986039 @default.
• W2079174302 creator A5079505297 @default.
• W2079174302 date "2000-05-15" @default.
• W2079174302 modified "2023-09-28" @default.
• W2079174302 title "Contribution of NF‐<i>κ</i>B and p53 in the glutamate‐induced apoptosis" @default.
• W2079174302 cites W1517251498 @default.
• W2079174302 cites W1549338235 @default.
• W2079174302 cites W1558367558 @default.
• W2079174302 cites W1566676785 @default.
• W2079174302 cites W1904788586 @default.
• W2079174302 cites W1920883260 @default.
• W2079174302 cites W1922231573 @default.
• W2079174302 cites W1940372773 @default.
• W2079174302 cites W1965149830 @default.
• W2079174302 cites W1966341306 @default.
• W2079174302 cites W1968786165 @default.
• W2079174302 cites W1970546664 @default.
• W2079174302 cites W1971489322 @default.
• W2079174302 cites W1973060929 @default.
• W2079174302 cites W1975690985 @default.
• W2079174302 cites W1977632821 @default.
• W2079174302 cites W1983704426 @default.
• W2079174302 cites W1985445237 @default.
• W2079174302 cites W1987469323 @default.
• W2079174302 cites W1990520196 @default.
• W2079174302 cites W1991743392 @default.
• W2079174302 cites W1991905088 @default.
• W2079174302 cites W1996860480 @default.
• W2079174302 cites W1997336945 @default.
• W2079174302 cites W1998669119 @default.
• W2079174302 cites W2001997105 @default.
• W2079174302 cites W2003742797 @default.
• W2079174302 cites W2008301561 @default.
• W2079174302 cites W2009685663 @default.
• W2079174302 cites W2012053348 @default.
• W2079174302 cites W2014461783 @default.
• W2079174302 cites W2015519364 @default.
• W2079174302 cites W2016575029 @default.
• W2079174302 cites W2023934610 @default.
• W2079174302 cites W2025122344 @default.
• W2079174302 cites W2031595027 @default.
• W2079174302 cites W2047590658 @default.
• W2079174302 cites W2049167261 @default.
• W2079174302 cites W2052124305 @default.
• W2079174302 cites W2053102794 @default.
• W2079174302 cites W2057215523 @default.
• W2079174302 cites W2059328439 @default.
• W2079174302 cites W2064483085 @default.
• W2079174302 cites W206889681 @default.
• W2079174302 cites W2070093243 @default.
• W2079174302 cites W2083932065 @default.
• W2079174302 cites W2085469946 @default.
• W2079174302 cites W2086997247 @default.
• W2079174302 cites W2133092640 @default.
• W2079174302 cites W2134617096 @default.
• W2079174302 cites W2139970952 @default.
• W2079174302 cites W2141372702 @default.
• W2079174302 cites W2150627157 @default.
• W2079174302 cites W2151982496 @default.
• W2079174302 cites W2171855511 @default.
• W2079174302 cites W2195336126 @default.
• W2079174302 cites W2317335867 @default.
• W2079174302 cites W2329132780 @default.
• W2079174302 cites W253594318 @default.
• W2079174302 cites W97692387 @default.
• W2079174302 doi "https://doi.org/10.1016/s0736-5748(00)00018-6" @default.
• W2079174302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10817929" @default.
• W2079174302 hasPublicationYear "2000" @default.
• W2079174302 type Work @default.
• W2079174302 sameAs 2079174302 @default.
• W2079174302 citedByCount "29" @default.
• W2079174302 countsByYear W20791743022013 @default.
• W2079174302 countsByYear W20791743022018 @default.
• W2079174302 countsByYear W20791743022019 @default.
• W2079174302 countsByYear W20791743022021 @default.
• W2079174302 crossrefType "journal-article" @default.
• W2079174302 hasAuthorship W2079174302A5023788664 @default.
• W2079174302 hasAuthorship W2079174302A5074986039 @default.
• W2079174302 hasAuthorship W2079174302A5079505297 @default.
• W2079174302 hasConcept C153911025 @default.
• W2079174302 hasConcept C170493617 @default.
• W2079174302 hasConcept C190283241 @default.
• W2079174302 hasConcept C502942594 @default.
• W2079174302 hasConcept C55493867 @default.
• W2079174302 hasConcept C61174792 @default.
• W2079174302 hasConcept C86803240 @default.
• W2079174302 hasConcept C95444343 @default.
• W2079174302 hasConceptScore W2079174302C153911025 @default.
• W2079174302 hasConceptScore W2079174302C170493617 @default.
• W2079174302 hasConceptScore W2079174302C190283241 @default.
• W2079174302 hasConceptScore W2079174302C502942594 @default.
• W2079174302 hasConceptScore W2079174302C55493867 @default.
• W2079174302 hasConceptScore W2079174302C61174792 @default.
• W2079174302 hasConceptScore W2079174302C86803240 @default.
• W2079174302 hasConceptScore W2079174302C95444343 @default.

• next