FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079175440> ?p ?o ?g. }

• W2079175440 endingPage "n/a" @default.
• W2079175440 startingPage "n/a" @default.
• W2079175440 abstract "Cyclooxygenase-2 (COX-2) plays major roles in diverse physiological and pathological processes such as inflammation and tumorigenesis. Transcriptional control of COX-2 has been extensively investigated and characterized, but its post-translational control is less clear. Here, we report a novel mechanism by which COX-2 is degraded. Protein levels of caveolin-1 (Cav-1) and COX-2 showed an inverse relation in colon cancer cell lines. COX-2 proteins in lung and colon tissues were higher in Cav-1 null mice than in wild-type mice. RNAi knockdown of Cav-1 increased COX-2 protein level and decreased ubiquitinated COX-2 accumulation. In addition, deletion of the carboxy (C)-terminus of COX-2, which contains a unique 19-amino acid segment compared with COX-1, resulted in reduced Cav-1 binding and attenuated COX-2 degradation. COX-1 and green fluorescence protein containing the C-terminus of COX-2 resulted in enhanced degradation. Our findings suggest that Cav-1 binds COX-2 in endoplasmic reticulum (ER) and carries it for degradation via ER associated degradation. The C-terminal region of COX-2 is required for Cav-1 binding and degradation. These results indicate a novel function of Cav-1 in controlling COX-2 expression, which may regulate physiological functions and have tumor suppression effects. J. Cell. Biochem. 109: 356–362, 2010. © 2009 Wiley-Liss, Inc." @default.
• W2079175440 created "2016-06-24" @default.
• W2079175440 creator A5000010847 @default.
• W2079175440 creator A5003714713 @default.
• W2079175440 creator A5018178028 @default.
• W2079175440 creator A5027837156 @default.
• W2079175440 creator A5035975194 @default.
• W2079175440 creator A5051153636 @default.
• W2079175440 creator A5057497997 @default.
• W2079175440 creator A5069404044 @default.
• W2079175440 creator A5087159924 @default.
• W2079175440 date "2009-01-01" @default.
• W2079175440 modified "2023-10-14" @default.
• W2079175440 title "Caveolin-1 facilitates cyclooxygenase-2 protein degradation" @default.
• W2079175440 cites W1648593433 @default.
• W2079175440 cites W1965546606 @default.
• W2079175440 cites W1976389898 @default.
• W2079175440 cites W1989693627 @default.
• W2079175440 cites W2024233889 @default.
• W2079175440 cites W2030727312 @default.
• W2079175440 cites W2034855589 @default.
• W2079175440 cites W2036913490 @default.
• W2079175440 cites W2042928324 @default.
• W2079175440 cites W2078247114 @default.
• W2079175440 cites W2087222747 @default.
• W2079175440 cites W2087728783 @default.
• W2079175440 cites W2090314062 @default.
• W2079175440 cites W2092305527 @default.
• W2079175440 cites W2094821493 @default.
• W2079175440 cites W2100136013 @default.
• W2079175440 cites W2108408322 @default.
• W2079175440 cites W2136061004 @default.
• W2079175440 cites W2149233326 @default.
• W2079175440 cites W2150668138 @default.
• W2079175440 cites W2151324251 @default.
• W2079175440 cites W2153244390 @default.
• W2079175440 cites W2167078220 @default.
• W2079175440 cites W4230326620 @default.
• W2079175440 doi "https://doi.org/10.1002/jcb.22407" @default.
• W2079175440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19960513" @default.
• W2079175440 hasPublicationYear "2009" @default.
• W2079175440 type Work @default.
• W2079175440 sameAs 2079175440 @default.
• W2079175440 citedByCount "21" @default.
• W2079175440 countsByYear W20791754402012 @default.
• W2079175440 countsByYear W20791754402013 @default.
• W2079175440 countsByYear W20791754402014 @default.
• W2079175440 countsByYear W20791754402016 @default.
• W2079175440 countsByYear W20791754402017 @default.
• W2079175440 countsByYear W20791754402018 @default.
• W2079175440 countsByYear W20791754402019 @default.
• W2079175440 countsByYear W20791754402022 @default.
• W2079175440 countsByYear W20791754402023 @default.
• W2079175440 crossrefType "journal-article" @default.
• W2079175440 hasAuthorship W2079175440A5000010847 @default.
• W2079175440 hasAuthorship W2079175440A5003714713 @default.
• W2079175440 hasAuthorship W2079175440A5018178028 @default.
• W2079175440 hasAuthorship W2079175440A5027837156 @default.
• W2079175440 hasAuthorship W2079175440A5035975194 @default.
• W2079175440 hasAuthorship W2079175440A5051153636 @default.
• W2079175440 hasAuthorship W2079175440A5057497997 @default.
• W2079175440 hasAuthorship W2079175440A5069404044 @default.
• W2079175440 hasAuthorship W2079175440A5087159924 @default.
• W2079175440 hasBestOaLocation W20791754401 @default.
• W2079175440 hasConcept C104317684 @default.
• W2079175440 hasConcept C139447449 @default.
• W2079175440 hasConcept C153911025 @default.
• W2079175440 hasConcept C158617107 @default.
• W2079175440 hasConcept C158619295 @default.
• W2079175440 hasConcept C173396325 @default.
• W2079175440 hasConcept C185592680 @default.
• W2079175440 hasConcept C190283241 @default.
• W2079175440 hasConcept C25602115 @default.
• W2079175440 hasConcept C2992195973 @default.
• W2079175440 hasConcept C502942594 @default.
• W2079175440 hasConcept C55493867 @default.
• W2079175440 hasConcept C555283112 @default.
• W2079175440 hasConcept C86803240 @default.
• W2079175440 hasConcept C95444343 @default.
• W2079175440 hasConceptScore W2079175440C104317684 @default.
• W2079175440 hasConceptScore W2079175440C139447449 @default.
• W2079175440 hasConceptScore W2079175440C153911025 @default.
• W2079175440 hasConceptScore W2079175440C158617107 @default.
• W2079175440 hasConceptScore W2079175440C158619295 @default.
• W2079175440 hasConceptScore W2079175440C173396325 @default.
• W2079175440 hasConceptScore W2079175440C185592680 @default.
• W2079175440 hasConceptScore W2079175440C190283241 @default.
• W2079175440 hasConceptScore W2079175440C25602115 @default.
• W2079175440 hasConceptScore W2079175440C2992195973 @default.
• W2079175440 hasConceptScore W2079175440C502942594 @default.
• W2079175440 hasConceptScore W2079175440C55493867 @default.
• W2079175440 hasConceptScore W2079175440C555283112 @default.
• W2079175440 hasConceptScore W2079175440C86803240 @default.
• W2079175440 hasConceptScore W2079175440C95444343 @default.
• W2079175440 hasLocation W20791754401 @default.
• W2079175440 hasLocation W20791754402 @default.
• W2079175440 hasOpenAccess W2079175440 @default.
• W2079175440 hasPrimaryLocation W20791754401 @default.

• next