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• W2079175995 abstract "Summary Background : Owing to rising drug‐resistant Helicobacter pylori infections, currently recommended proton‐pump inhibitor‐based triple therapies are losing their efficacy, and regimens efficacious in the presence of drug resistance are needed. Aims : To summarize the efficacy, safety and adherence of first‐line quadruple H. pylori therapies in adults. Methods : Meta‐regression models identified factors explaining variation in the efficacy of first‐line quadruple therapies from 145 treatment arms. Estimates of average efficacy were calculated within homogeneous groups. Results : Quadruple therapy containing a gastric acid inhibitor, bismuth, metronidazole and tetracycline was enhanced when omeprazole was included, treatment duration lasted 10–14 days, and when therapy took place in the Netherlands, Hong Kong and Australia. Treatment efficacy decreased as the prevalence of metronidazole resistance increased. Even in areas with a high prevalence of metronidazole resistance, this quadruple regimen eradicated more than 85% of H. pylori infections when it contained omeprazole and was given for 10–14 days. Furthermore, in the presence of clarithromycin resistance, this quadruple regimen eradicated 90–100% of H. pylori infections, while the currently recommended triple therapy containing clarithromycin, amoxicillin and a proton‐pump inhibitor eradicated only 25–61% ( P < 0.001). Adherence and adverse events for quadruple therapy were similar to currently recommended triple therapies. Conclusions : Guidelines should include quadruple therapy with a proton‐pump inhibitor, a bismuth compound, metronidazole and tetracycline among recommended first‐line anti‐ H. pylori therapies." @default.
• W2079175995 created "2016-06-24" @default.
• W2079175995 creator A5041177228 @default.
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• W2079175995 date "2004-11-01" @default.
• W2079175995 modified "2023-10-15" @default.
• W2079175995 title "Meta-analysis: the efficacy, adverse events, and adherence related to first-line anti-Helicobacter pylori quadruple therapies" @default.
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• W2079175995 doi "https://doi.org/10.1111/j.1365-2036.2004.02248.x" @default.
• W2079175995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15569109" @default.
• W2079175995 hasPublicationYear "2004" @default.
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